Associate Scientist, Protein Engineering & Binder Optimization

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Job Description

We are seeking a highly motivated and detail‑oriented Associate Scientist to join the Protein Engineering & Binder Optimization group within Kite Research. This role is primarily bench‑focused and execution‑driven, with a strong emphasis on hands‑on laboratory support for high‑throughput protein expression, purification, and analytical characterization.

The Associate Scientist will be a critical contributor to discovery and optimization programs, serving as a reliable experimental operator who enables scale, speed, and data quality across multiple protein engineering efforts. This position is well‑suited for an individual who thrives in a fast‑paced research environment, values rigor and reproducibility, and is excited to build deep technical expertise in protein production and analytics.

Key Responsibilities

High‑Throughput Protein Expression & Purification (Primary Focus)

• Execute high‑throughput cloning, expression, and purification of recombinant proteins and binders across multiple formats (e.g., bacterial, mammalian, or yeast systems, as applicable).

• Perform parallelized small‑scale and mid‑scale protein production to support binder discovery and optimization workflows.

• Prepare purified proteins for downstream applications, ensuring appropriate quality, concentration, and documentation.

• Rigorously track samples, constructs, and yields using electronic lab notebooks and sample management systems.

Protein Characterization & Analytics

• Perform routine and advanced protein analytical assays, such as SDS‑PAGE, SEC, ELISA, and concentration/quality assessments.

• Support binding and functional characterization efforts (e.g., sample preparation for SPR/BLI, cell‑based assays, or functional screens).

• Assess protein quality, stability, and suitability for downstream assays; flag issues and propose troubleshooting steps.

Experimental Execution in Discovery Programs

• Provide consistent, high‑quality experimental execution in support of binder discovery, optimization, and validation campaigns.

• Work from protocols while developing the technical judgment to recognize deviations, failures, or optimization opportunities.

• Generate clear, reproducible, and decision‑ready experimental data that feeds directly into program workflows.

Workflow Support & Continuous Improvement

• Contribute to the robustness and scalability of protein production and analytical workflows.

• Identify opportunities to improve throughput, reproducibility, or data quality through protocol refinement and standardization.

• Maintain well‑organized lab spaces, reagents, and shared resources to support efficient team operation.

Collaboration & Communication

• Collaborate closely with Scientists and computational partners within the larger Protein Science team

• Communicate experiment status, results, and issues clearly in team discussions and written records.

• Engage constructively with cross‑functional partners (e.g., Cell Biology, Translational teams) as needed for sample handoff and assay support.

Basic Qualifications

• Master’s degree with 2+ years of relevant scientific experience
  OR

• Bachelor’s degree with 4+ years of relevant scientific experience

Preferred Qualifications

• Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Protein Science, Bioengineering, or a related discipline

• Hands‑on laboratory experience in recombinant protein expression and purification

• Demonstrated ability to execute repetitive, high‑throughput wet‑lab workflows<