Development Scientific Director

Job title: Development Scientific Director

Location: Cambridge, MA / Morristown, NJ / Washington, DC

About the job

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions. 

We are seeking an accomplished Development Scientist Director with deep expertise in ophthalmology and gene therapy programs to drive the execution of complex global clinical trials. He/she is a responsible member of the clinical team dedicated to the development and execution of clinical strategies and the clinical and operational implementation of a complex compound program. The primary purpose of the Development Scientist Director's position is to support the Clinical Research Director (CRD) and/or clinical lead in the medical/scientific contribution for the clinical studies on activities pertaining to the Study Medical Manager (SMM) responsibilities e.g.: leading or contributing to key study documents and activities from clinical development plans and trial set-up to clinical study report in compliance with quality and regulatory processes.

It is expected the Development Scientist Director provides active scientific contribution to a cross-functional clinical team developing a molecular entity, provide input to the clinical development plan, work on the development of the clinical trial protocol and amendments, clinical trial materials, and take responsibility for coordinating completion of clinical study reports and support preparation of relevant documents for regulatory filings. This role will involve extensive team matrix interactions with colleagues from a number of different disciplines and development scientist is responsible for  leading or representing clinical development across specific aspects of clinical trial execution. This individual may be asked to contribute to the evaluation of scientific opportunities in the therapeutic area.

This role will also serve as a strategic lead responsible for end-to-end study oversight, from feasibility through study close-out, ensuring delivery of high-quality data on time and within budget.

About Sanofi 

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. 

Main Responsibilities:

Therapeutic Expertise

• Required: Ophthalmology clinical trial experience including gene therapy (retinal diseases, nAMD, geographic atrophy, etc.)

• Experience with first-in-class compounds and novel therapeutic modalities

Program Leadership & Strategy

• Leadership skills to give direction, organize activities and progress deliverables on behalf of the clinical research director (CRD)

• Serve as the development representation for strategy and execution for global Phase I-III ophthalmology clinical programs, including gene therapy and novel therapeutic modalities

• Serve as a primary development point of contact for CROs, vendors, investigative sites, KOLs, and internal cross-functional teams

• Drive program development activities including feasibility, site selection, start-up, enrollment strategies, and study timelines

• Ensure achievement of corporate enrollment goals and study milestones ahead of schedule

• Proactively identify and mitigate risks to maintain program timelines and quality standards

Cross-Functional Collaboration

• Partner with Medical, Regulatory, Quality, Clinical Supply, Data Management, and Biostatistics teams to ensure seamless study execution

• Collaborate with Key Opinion Leaders (KOLs) and investigative sites to develop protocols, training materials, and operational strategies

• Build trust and credibility with external stakeholders to strengthen company brand and investigator relationships

• Lead internal and external cross-functional team meetings to drive alignment and decision-making

Team Leadership & Development

• Build, mentor, and manage clinical operations teams including Clinical Project Managers, CTAs, and CRAs

• Provide guidance and professional development to direct reports

• Participate in hiring decisions and onboarding of new team members

• Foster a collaborative, high-performance team culture

Study Execution Excellence

• Oversee study start-up activiti