Associate Director Discovery Toxicology

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Associate Director in Discovery Toxicology 

When you join BMS, you are joining a diverse, high-achieving team united by a common mission. 

The Pharmaceutical Candidate Optimization organization at Bristol Myers Squibb is a dynamic, multi-disciplinary department that works to discover and optimize new drug candidates.  We work across all therapeutic areas and all modalities (small molecules, biotherapeutics, gene and cell therapies and other novel modalities), and engage with all other R&D functions to advance new assets in the BMS portfolio.  Our integrated, cross-functional teams apply deep expertise in drug metabolism, pharmacokinetics (DMPK), toxicology, pharmaceutics, and bioanalysis to identify and solve issues, discover high quality drug candidates, and enable their clinical development.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

A position is available for an Associate Director in Discovery Toxicology (DT) within the Pharmaceutical Candidate Optimization (PCO) organization at BMS.  The incumbent will have responsibilities to identify and address toxicology issues across discovery programs that inform on program advancement, optimization of lead candidates and progression into development.  Scientists in DT work with biology, chemistry and biotherapeutics representatives along with integrating across the other disciplines in PCO, namely drug metabolism and pharmacokinetics (DMPK) and pharmaceutics and bioanalytical sciences (DPAS) to ensure that quality drug candidates are advanced into development. 

Responsibilities:  

·       Assess and develop plans for evaluating potential toxicity of new drug targets  

·       Apply appropriate models and testing strategies that inform on mechanisms of toxicity, address relevance to humans and design appropriate tools that can be used to proactively evaluate and predict liabilities of new drug entities 

·       Design, conduct, interpret toxicology studies within drug discovery and communicate these results across multiple disciplines and governance bodies 

·       Participate in drug discovery teams as a toxicology expert including communication of issues, experimental strategies for resolution and interpretation of results. 

·       Contribute to the collective research expertise in DT including laboratory efforts to advance new tools for advancing mechanistic toxicology research 

·       Discuss and enable transition of drug candidates into the BMS Development organization