Associate Scientist I/II, Process Development - Downstream

 About Forge  

Forge, a member of Ajinomoto Bio-Pharma Services, is a gene therapy development engine, focused on enabling access to life changing gene therapies and helping bring them from idea into reality. We partner with innovators in the gene therapy community: scientists, physicians, biotech/pharma companies, and patient groups. We bring expertise in gene therapy manufacturing and therapeutics development to the table, helping to champion teams that are navigating the long road from the lab bench to the bedside. Our goal is simple but vital to patients living with disease, and we take it seriously. With a patient-first approach, we are forging new models for working together to better accelerate these transformative medicines to reach those who need them the most.   

 

Forge is based in Columbus, Ohio, in a 200,000 square foot facility known affectionately by team members as, the Hearth. The Hearth, is a custom-designed cGMP facility dedicated to AAV manufacturing and hosts scalable, end-to-end manufacturing services.  

About The Role

We are currently seeking a Associate Scientist I or II, Process Development - Downstream to join the Forge Biologics team. This is an exciting opportunity to assist in the execution of laboratory experiments and protocols for downstream process development efforts. The candidate will assist in process development protocols/studies to optimize procedures for unique viral vector platform process and to assist in the transfer of client programs.

 

What You’ll Do

• Assist with overall maintenance of the production facilities. This includes but may not be limited to performing quality systems checks, buffer preparation, autoclaving of materials, packing of biohazard material, monitoring, or sanitizing equipment, preparing facility for production campaigns, and periodic cleaning of centrifuges, FPLCs, biological safety cabinets (BSCs), and other equipment.
• Purifying viral vectors in a variety of means such as: density gradients, FPLC, tangential flow filtration (TFF), or other techniques.
• Maintain both written and electronic records in accordance to GLP protocols.
• Assist in maintaining proper inventories of raw materials and consumables.
• Prepares formulations and raw materials as specified in protocols without the introduction of contaminants.
• Maintains clean work environment in all work areas.
• Occasionally present both written and oral study/experimental results with internal departments.
• Reports any discrepancies from protocols/study procedures or any materials preparation problems to management.
• Work seamlessly with cross functional stakeholders including Analytical Development, Project Management, and Supply Chain to help advance AAV vector production.
• Delivering results in a high paced environment
• Package and ship finished product to clients in accordance with procedures and regulations.

 

What You’ll Bring

• Bachelor’s degree in Biology, Molecular Biology, Chemistry, Chemical Engineering, Biochemistry or related discipline
• 1-2 years of biotechnology, medical device, or research laboratory experience.

 

Preferred Skills  

• Practical experience with FPLC (Fast Protein Liquid Chromatography)
• Experience with other aspects of downstream purification (e.g. – clarification/filtration, TFF, etc.)

 

Work Environment and Physical Demands  

This position works in both a laboratory environment and typical office environment where the physical work demands will vary depending on the specific tasks and duties required of the job. The employee will be stationary (standing/sitting) for extended periods of time. Employees regularly wear personal protective equipment based on the task being performed. Must be able to work in a confined space, such as a clean room or laboratory environment. Ability to identify small details within the field of vision, distinguish between different colors, and accurately identify objects within a specific area. 

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change or new ones may be assigned. 

 

Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce. Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, g