Computational Biologist II, CellxState

<div class="content-intro"><p>Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.</p></div><h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">The Team</span></h2> <p>Through our multi-dimensional imaging program, we build imaging tools that capture life across scales — from single proteins to whole organisms — revealing how proteins and cells function, communicate, and assemble into living systems. These observations are laying the groundwork for a new generation of AI models that can predict cellular behavior and guide the development of better treatments for widespread diseases. You can learn more about our work <a href="https://biohub.org/imaging/">here</a>.&nbsp;</p> <p>Our work brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine.&nbsp;</p> <p><strong>Our Vision</strong></p> <ul> <li>Pursue large scientific challenges that cannot be pursued in conventional environments</li> <li>Enable individual investigators to pursue their riskiest and most innovative ideas</li> <li>Facilitate research by scientists and clinicians at our home institutions and beyond</li> </ul> <p>We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.</p> <h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">The Opportunity</span></h2> <p>Part of the Imaging Grand Challenge, The CELLxSTATE Program builds next-generation technologies to decode and control how cells make decisions — combining live-cell imaging, multi-omics, and AI at unprecedented scale.&nbsp; We also create large reference datasets that can be mined and reused by the entire community for discovery, like our OpenCell project that maps protein localization and interactions (<a href="https://opencell.czbiohub.org/">https://opencell.czbiohub.org/</a>). Our science is fully open-source and published in journals like Science, Nature Methods, and Cell (<a href="https://biohub.org/leonetti/publications/">https://biohub.org/leonetti/publications/</a>).</p> <p>At the core of our current efforts is multiDPS (Multimod