Director, Drug Metabolism

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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
 

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
 

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description
 

The primary responsibility of this position is to design and conduct or monitor experiments to understand the metabolism and drug-drug interaction (DDI) properties of drug candidates, particularly the quantitative roles of enzymes in the disposition of those drug candidates (metabolic phenotyping).  More broadly, the scientist is expected to integrate this information with absorption, distribution and excretion data for these compounds for a full understanding of their drug metabolism and pharmacokinetic (PK) behavior.  This will include representation of the department on multidisciplinary project teams.  Supervision and mentoring of other scientists and/or laboratory staff will be required. This role will be based in our headquarters in Foster City, CA.

Essential Duties and Job Responsibilities:

• Through guidance of other staff and external resources, and through direct laboratory work conduct studies to determine the kinetics of metabolism of drug candidates and to determine the roles of various enzymes in the metabolic profiles of those compounds.

• Serve as a drug metabolism and enzyme kinetics subject matter expert for multiple dynamic cross-functional teams, to define strategies to achieve target product profiles, integrate in vitro and in vivo drug disposition data, interpretation, and give presentations to teams.

• Work closely with internal and external resources to assure timely delivery of high-quality data.

• Provide clear verbal communication of results and strategies at group, department, project team and management level.  Write research reports and regulatory documents. 

• Contribute to science through conference presentations and publication of new findings.

Basic Qualifications:

Bachelor's Degree and Twelve Years’ Experience

OR

Masters' Degree and Ten Years’ Experience

OR

PhD and Eight Years’ Experience

Preferred Qualifications:

• A highly motivated individual with PhD degree in life sciences with 8 - 10 years of post-doctoral and/or industry experience directly related to the Specific Responsibilities listed above (hands-on experience and deep knowledge of enzymology and enzyme kinetics).

• A significant advantage would be hands-on experience in application of the enzymology data in physiologically-based PK (PBPK) modeling (using e.g. Simcyp, GastroPlus or custom models)

• Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.

• Expertise and experience in one or more of the following areas:<