At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine   
 

We are searching for the best talent for a Senior Scientist, Global Proteomics to be located in Cambridge, MA.
 

Purpose: Do you want to use your hard-earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis.
 

Be part of a motivated team deploying cutting-edge mass spectrometry technologies to tackle challenges in end to end drug discovery and development. Work across a leading multiomics organization to provide coordinated insights across a variety of 'omics layers.
 

This is a hands-on laboratory role with project leadership responsibilities—fit for a scientist who thrives at the bench and also enjoys crafting experimental strategy, presenting results, and representing proteomics in cross-functional project teams. With your help, we will drive development of medicines for our patients!
 

You will be responsible for:

• Joining a team of wet lab scientists enabling proteomic impact across a wide variety of programs and therapeutic modalities.
   
• Planning and performing wet lab proteomic activities supporting evaluation of therapeutic candidates and drive SAR enabled risk mitigation of small molecules.
   
• Operating and maintaining LC-MS instrumentation (Thermo Orbitrap Exploris/Eclipse/Astral, Bruker timsTOF; LC systems such as Vanquish Neo, Evosep One, UltiMate 3000) with full responsibility for daily/weekly maintenance, calibration, and troubleshooting.
   
• Deploying automation-supported workflows for high-throughput sample prep using platforms such as Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, or Dynamic Devices Lynx.
   
• Ensuring QC and reproducibility, including system suitability checks, performance tracking, and SOP documentation.
   
• Serving as proteomics point of contact for assigned drug discovery project teams. Collaborating with project leads to define experimental strategy, timelines, and expected results from the proteomics perspective.
   
• Communicating study design, progress, and results clearly to cross-functional team members (chemistry, biology, safety, DMPK, bioinformatics).
   
• Demonstrating creativity and apply novel approaches to solving scientific problems. Propose novel and practical ideas, aligned with scientific strategies and demands.
   

Qualifications / Requirements

Education:

• A Doctoral degree in Chemistry, Biochemistry, Chemical Biology, or a related field) is required.

Experience and Skills:

Required:

• 3+ years of proven hands-on experience operating and troubleshooting LC-MS systems independently for proteomics (academic core or industry).
   
• Experience with label-free proteomics workflows and robust sample preparation techniques as well as data processing suites Proteome Discoverer, MaxQuant, DIA-NN, Spectronaut, or Skyline.
   
• Excellent interpersonal and communication skills for cross-functional collaboration and pro