Senior Scientist, High-Throughput Experimentation

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Chemical Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, High-Throughput Experimentation to be located in Spring House, PA.

Purpose: We are seeking a highly motivated Senior Scientist to join our High-Throughput Experimentation (HTE) Center of Excellence within Global Discovery Chemistry (GDC). This unique role provides an unprecedented opportunity to contribute to the impact of our state-of-the-art capabilities on Johnson & Johnson’s evolving pipeline and to further innovation in the high-throughput technologies space.

In GDC, we deliver high quality drug candidates in close partnership with all Johnson & Johnson Therapeutic Area (TA) discovery teams. The successful scientist will join a team consisting of chemists with a diversity of skills including Medicinal Chemistry, Automated Synthesis, Computational Chemistry, Cheminformatics, Data Science, Analytical Chemistry etc. They will use state-of-the art techniques and instrumentation to design and synthesize drug candidates to advance drug discovery projects across a range of modalities. Acceleration of discovery programs through application of high-throughput experimentation, high-throughput synthesis, reaction automation and AI/ML approaches will be a focus.

You will be responsible for:

• Designing and executing automated experiments to optimize chemical reactions or discover new transformations that impact progression of discovery leads.
   
• Designing and performing HTE experiments to generate reaction data to fuel synthesis prediction efforts and AI/ML models applicable to J&J’s internal programs.
   
• In close collaborations with partners across other functions (i.e., Biochemistry, Pharmacology, Data science), contributing to the evolution and application of our Direct-to-Biology (D2B) platform by designing, validating and completing semi-automated and automated experiments to effectively accelerate the discovery portfolio and Design-Make-Test-Analyze cycles.
   
• Designing and executing semi-automated and automated experiments to effectively carry out structure-activity relationships (SAR) campaigns on drug discovery projects.
   
• Identifying broad implications of data including data capture and data mining from HTE and parallel experiments.
   
• Streamlining workflows and developing automated laboratory processes.
   
• Becoming an expert in high-throughput synthesis workflows in J&J and provide training to Global Discovery Chemistry team members on HTE and D2B workflows when necessary.
   
• Learning programming and debugging with Python, Pipeline Pilot, relational databases, SQL, LIMS or other relevant enterprise software packages.
   
• Proactively and clearly providing project status updates to key partners, through various channels including in-person and virtual meetings.

Qualifications / Requirements:

Education:

• A minimum of a Bachelor's degree in Chemistry or a related field is required. An advanced degree (Master's, PhD) is preferred.

Experience and Skills:

Required:

• At least 4 years of relevant experience (e.g., PhD, post-doc, industry experience with automated synthesis workflows) i