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Principal Research Scientist I, Discovery Biotherapeutics

AbbVie
South San Francisco, United Statesfull_timeVerifiedPosted 9 Jan 2026

About the role

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on XFacebookInstagramYouTubeLinkedIn and Tik Tok.

Job Description

Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated Principal Scientist to join the Biotherapeutics group at the AbbVie Bay Area (ABA) site based in South San Francisco, CA. This role seeks a skilled and experienced individual to contribute to and lead therapeutic programs, focusing on biophysical screening to advance biotherapeutics from early exploration through lead identification and optimization. Close partnerships with Oncology will be required to drive transformative ideas to the clinic. The ideal candidate must possess expertise in high-throughput biologics screening and characterization methods (e.g. ELISA, FACS, BLI, SPR, etc.) and have a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams.

Responsibilities

  • Lead from the lab to advance large molecule biologics projects from exploratory to optimization stages and drive Go / No Go decisions.
  • Effectively partner with functional and therapeutic areas to achieve project objectives.
  • Identify and integrate cutting-edge technologies and methodologies into screening and assay development, anticipating future trends in drug discovery.
  • Multitask and work within timelines while maintaining a high level of productivity.
  • Supervise 1-2 scientists, evaluate team performance, and is accountable for the effective performance of team

Qualifications

  • BS, MS, or PhD with typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of relevant experience.
  • Experience with biologics, monoclonal antibodies and/or protein therapeutics.
  • Experience advancing Discovery programs from exploratory

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Company

AbbVie

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