Senior/Principal Scientist, Immunology, Genetics, Gastrointestinal Disease Biology, and Drug Development

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.  Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

Calico is seeking a highly motivated scientist to join and lead discovery research projects in the Immunology and Gastroenterology group. Specifically, we are interested in applicants with a long-term interest in understanding the aging mechanisms of immunological and gastrointestinal diseases, with a particular emphasis on inflammatory regulatory pathways and metabolic pathways. We seek expertise in applying cutting-edge biochemical, molecular, and cell biological techniques, including microscopic and "omics" technologies, to unlock the complexities of immune and gastrointestinal physiology with experience in developing new therapeutics for aging, aging-related diseases, and cancer. Join our collaborative, cross-functional environment at the forefront of aging research, work alongside world-class technology labs, and lead ambitious research projects that transform our understanding of aging to develop innovative therapeutics for aging and aging-related diseases.

Position Requirements:

• PhD or equivalent degree in immunology, cell biology, or related fields, with 5-10 years of postdoctoral and/or industry experience
• Creative and critical thinking skills
• Strong interpersonal communication skills, both verbal and written
• Strong technical skills at the bench
• Drug development experience leading to new molecular entities leading to clinical trials
• Track record of impactful publications and patents
• Technical expertise in the following areas: multi-color flow cytometry, live cell imaging, molecular techniques, and primary immune cell and cell line culture, transfection, transduction, and CRISPR technologies
• Expertise in mouse work and organ analysis
• Must be willing to work onsite five days a week

The estimated base salary range for this role is $166,000 - $207,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.