Senior Molecular Imaging Expert (Senior Principal Scientist)

Job Description Summary

Senior Molecular Imaging Expert (Senior Principal Scientist)

#LI-Hybrid

About the role:

The Biomarker Development (BMD) group at the Novartis BioMedical Research is seeking a Senior Molecular Imaging Expert to join our Clinical Imaging & Analytics team. Join an imaging team that has extensive knowledge of structural and molecular biomarkers and their use in clinical and translational drug development. You will work with clinical trial teams to determine the role of imaging endpoints along new biological pathways across different therapeutic areas. The role offers a wide view of molecules across various stages as they transition from research to early development and subsequently to Ph2-3 trials. As a part of building imaging endpoints, the role also provides unique exposure to variety of other critical biomarkers (soluble and genetics) for an integrated view of identifying unique patient populations and novel readouts of efficacy and safety.

 

Job Description

Key Responsibilities:

• Act as an internal expert in PET/SPECT and Molecular Imaging with focus on clinical trials
• Partner with Oncology and General Medicine teams to develop and lead “fit for purpose” imaging strategy and execute on it.
• Implement Imaging in clinical trials to add critical insights on patient eligibility, efficacy, safety, and mechanism of action.
• Collaborate and execute imaging readouts with internal operational support and external contract research organizations (CRO).
• Ensure quality and timely execution of imaging trials to deliver critical drug development decisions; be agile and responsive to clinical teams during the course of design, execution and interpretation of imaging trials.
• Develop and manage network of external experts; be able to synthesize optimal inputs and customize for specific protocols.
• Collaborate with Research teams to develop and lead translational imaging studies.
• Drive molecular imaging and ligand development from late pre-clinic to clinic
• Identify and/or develop novel imaging techniques and endpoints and implement them into clinical trials.

Essential Requirements:  

• PhD or MD or MD/PhD with 5+ years of experience in PET/SPECT Imaging in academia or industry ; Industrial experience in clinical trial & translational research is highly desirable
• Must have deep technical knowledge in PET and SPECT as applied to in-life readouts (preclinical and clinical)
• Expertise at the intersection of biomarkers and clinical needs along different stages of drug development
• Ability to balance external science (e.g., literature, KOL inputs) with optimal needs in projects.
• Demonstrated track record of innovative research preferably across imaging modalities
• Strong understanding of clinical trial design, statistics for endpoints and clinical data flow is required. Experience with clinical protocol writing across various line functions is required
• Track record of project management and experience working with imaging CROs; Understanding of sites, budgets and experience with multisite trials is a plus
• Proactive, self- motivated and independent working style. Used to work in a multidisciplinary team and understand the needs and goals of the broader organization

Desirable Requirements: 

• Experience in clinical Radioligand/Radiopharmaceutical Therapy (RLT/RPT)
• Expertise in Radiochemistry, novel ligand development from bench to clinic
• Experience in Regulatory submission, FIH , Dosimetry and receptor occupancy of molecular ligands

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