Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l'international, l'anglais étant la langue de travail. 

This job offer is accessible to all, regardless of gender. 

Intitulé du poste : Senior Scientist Specialized in Mass Spectrometry

• Location: Sisteron, France

About the job

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started? 

Sanofi is seeking a highly motivated senior scientist to join our mass spectrometry analytical laboratory. This laboratory is part of the Synthetic platform within the Global CMC Department that is striving to become an industry leader in the development of transformative medicines. 

The primary responsibility of this position is to perform structural characterization by interpretation of fragmentation mass spectra of synthetic small molecules and to manage analytical CMC projects. This position is onsite and is based in Sisteron, France. 

Main Responsibilities : 

• Develop and implement UPLC/HRMS ( Ultra Performance Liquid Chromatography / High Resolution Mass Spectrometry) : Electrospray Ionization (EI) and Atmospheric Pressure Chemical Ionization (APCI) and GC/MS (Gas Chromatography / Mass Spectrometry) : Electron Ionization and Chemical Ionization methods for the structural characterization by interpretation of fragmentation mass spectra of synthetic small molecules (active pharmaceutical ingredient, process intermediates, impurities and degradants) in the context of chemical development projects, analytical expertise and production troubleshooting
• Develop, validate UPLC/HRMS ( Ultra Performance Liquid Chromatography / High Resolution Mass Spectrometry) and GC/MS (Gas Chromatography / Mass Spectrometry) based quantitation methods for small molecules (ultratraces, mutagenic molecules, nitrosamines…) including writing of the documentation (protocols, reports, methods)
• Ensure the reliability and traceability of results obtained. Can review analytical experiences performed by expert mass spectrometry technicians
• Manage projects as a local analytical representative or as an Analytical Team Leader in project teams. Represent your unit or department within project teams and during internal scientific presentations
• Take part in project meetings with collaborators in other teams, departments and countries. The oral and written communication in French and in English is not a problem!
• Write the corresponding analytical section for clinical and submission dossier
• Propose and lead innovation initiatives, individually or in a team, in the mass spectrometry domain, propose innovative solutions for increased efficiency and ensure their visibility internally (meetings, events) and externally (publications, conferences, seminars)
• Manage equipment park (UPLC/HRMS and GC/MS) to insure performance maintenance and systems qualification

About you

Education:

• Master degree or analytical chemistry Engineer (or equivalent) with significant experience more than 8 years or PhD in analytical chemistry with more than 4 years of significant experience (with interpretation of fragmentation mass spectra of synthetic small molecules skills)

Experience:

•  Specialized in high-resolution mass spectrometry for structural analysis (interpretation of fragmentation mass spectra (Full scan, MSn)
• Development and validation of UPLC/MS ( Ultra Performance Liquid Chromatography / High Resolution Mass Spectrometry) and GC/MS (G