Executive Director, Thought Leader Liaisons (TLLs)

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Executive Director, Thought Leader Liaisons (TLLs)

National Hepatology & GI TLL Team – Madrigal Pharmaceuticals
Remote | ~60–75% Travel

About the Role

We are seeking an experienced, strategic, and people-centered leader to serve as our Executive Director of Thought Leader Liaisons (TLLs).  This national, second-line leadership role will lead the Hepatology/GI TLL organization and plays a central role in shaping how Madrigal engages Thought Leaders across the country.

Reporting to the Vice President of TLLs, you will help translate national strategy into impactful TLL field execution, elevate organizational capabilities, and develop high-performing leaders who support one of the most meaningful launches in hepatology.

This is a rare opportunity to influence a therapeutic category, shape a growing organization, and lead the team that serves as Madrigal’s face to the Hepatology and GI Thought Leader community.

Key Responsibilities

National Leadership & People Development

• Lead and develop a team of Senior Directors of TLLs across the U.S.
• Build a culture of accountability, strategic thinking, and continuous professional development.
• Oversee performance management, capability building, and succession planning for the TLL organization.

Strategic Partnership & Execution

• Serve as a senior thought partner to the VP of TLLs on national strategy, deployment, and continuous innovation.
• Translate strategy into clear, consistent execution plans across zones and teams.
• Guide leaders in identifying opportunities, refining tactics, and ensuring field excellence.

Thought Leader Engagement Excellence

• Lead national Hep/GI TLL execution to accelerate the launch of Resmetirom and ongoing lifecycle preparedness. 
• Ensure high-quality Thought Leader engagement and timely, actionable insights.
• Monitor KPIs, performance trends, and field feedback to drive improvements and consistent excellence.

Cross-Functional Collaboration

• Partner closely with Marketing, Market Access, Sales, Medical Affairs to ensure integrated customer engagement.
• Collaborate closely with the National Endocrinology Senior Director of TLLs to ensure cohesive, coordinated ways of working at the field level, especially within shared accounts and institutions.
• Represent the TLL function in cross-functional forums and help ensure alignment across the organization.

Resource & Capability Development

• Inform and co-lead the creation, optimization, and deployment of field tools, training, and processes that elevate TLL effectiveness.
• Integrate real-world insights into continuous improvement of resources and field capabilities.

Qualifications

Required

• Bachelor’s degree (advanced degree preferred).
• 15+ years progressive commercial or field experience in pharma/biotech.
• Minimum of 4 years leading TLL teams, including leadership of leaders (national or second-line highly preferred).
• Track record of success in specialty product launches and complex field execution.
• Deep understanding of the Hepatology, GI, or metabolic disease Thought Leader ecosystem.
• Exceptional people leadership, executive presence and communication, strategic thinking, and organizational development skills.
• Strong business acumen and ability to translate strategy into operational plans.
• Commitment to compliance and ethical engagement.