Senior Scientist, Cellular & Molecular Toxicology, Translational Safety

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Nonclinical Safety

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Cellular & Molecular Toxicology, Translational Safety to be located in San Diego, CA.

Purpose: The Senior Scientist will join the Cellular & Molecular Toxicology (CMT) team within Preclinical Sciences & Translational Safety (PSTS) to apply cell-based screening and mechanistic toxicity support for investigative studies. This role involves designing and conducting robust experiments to assess target liability and toxicity mechanisms, while developing assays suitable for de-risking observations in drug discovery & development. The position requires a collaborative spirit and exemplary communication skills to effectively work in a matrixed team environment engaging with stakeholders from various functions.

You will be responsible for:

Experimental Design & Execution:

• Design and conduct cell-based screening / mechanistic assays to address toxicity challenges.
• Develop and validate fit-for-purpose assays suitable for investigating target organ toxicity or mechanistic findings.

Investigative Studies:

• Utilize advanced cellular and molecular techniques for toxicity evaluations arising from nonclinical findings
• Incorporate organotypic models such as spheroids, microphysiological systems, and co-culture approaches to study toxicity mechanisms

Collaborative Problem Solving:

• Work with cross-functional teams and contribute to solving scientific problems across multi-disciplinary domains.

Scientific Communication:

• Analyze and interpret experimental data to create scientific presentations and reports.
• Maintain proper recording of information in electronic laboratory notebooks
• Present findings to supervisors, project teams, and stakeholder groups.
• May also serve as a functional representative on laboratory based site committees

Qualifications

Education:

• Ph.D. in Cell Biology, Toxicology, Pharmacology, or a related scientific discipline with 2-5 years postdoctoral training in academia or industry setting. MS degree with 10 years of experience will also be considered.

Experience/Skills:

Required Expertise:

• Strong laboratory experience in cell-based models and assay development.
• Background in cellular and molecular biology
• Proficiency in techniques such as cell culture, western blots, flow cytometry, PCR, ELISA, and immunofluorescence imaging.
• Knowledge of 3D culture techniques, spheroids, and microphysiological systems.

Skills:

• Strong analytical, documentation, and presentation skills.
• Ability to design mechanistic and hypothesis-driven investigations.
• Proficiency in software such as GraphPad Prism, Microsoft Office Suite (Excel, Word, PowerPoint).

Preferred:

• Experience in organotypic systems incorporating immune or multiple cell types.
• Familiarity with drug modalities beyond small molecules.

The expected pay range for this position is $105,000 to $169,050.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelin