TEMP - Scientist, Lead Generation Biology

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)

About the Role:

We are seeking a highly-motivated, collaborative and experienced drug hunter who will become an integral member of the growing in vitro pharmacology team. The successful candidate will support and lead multiple drug discovery project teams. As an integral member of the pharmacology team, candidate will support lead optimization campaigns and multiple new target screening efforts in the context of multidisciplinary project teams. The candidate will work on a broad range of assay technologies/platforms and a wide variety of automated equipment in a collaborative and dynamic work environment. Contributes to process efficiency and research quality. The work is fast-paced and process-oriented in an environment where efficiency and continuous improvement are integral goals.

_

Your Contributions (include, but are not limited to):

• Develops robust biochemical and cell-based assays, supporting the drug discovery process, and rapidly delivering robust SAR data

• Designs, optimizes, validates, executes & analyzes in vitro pharmacology assays under minimal supervision to generate high quality, reproducible results

• Perform routine assays to support lead identification & optimization

• Develop, optimize, and perform deep dive explorations of MOA

• Responsible for data analysis, reporting and presentation to internal/external teams

• Experience with cell/tissue culture of recombinant and/or primary cells

• Provides recommendations to improve on process efficiency and research quality

• Performs MOA studies, such as neurite outgrowth, electrophysiology, MEA, and immunostaining

• Critical analysis and insightful interpretation of biochemical, cell-based functional, and binding assay data to identify lead compounds & contribute to understanding of potency & MoA

• Tracks and documents assay performance

• Continually provides recommendations to improve on process efficiency and research quality

• Responsible for documenting protocols in an electronic laboratory notebook and regularly presenting clear written & verbal data summaries

• Other duties as a