Vice President, Head of Clinical Development

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. 

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness

• ​Financial Wellness

• Support for Caregivers
   

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
 

The Importance of the Role

The Vice President, Clinical Development is an enterprise‑level leader responsible for the strategic direction, execution, and accountability of the company’s clinical development portfolio. This leader drives the clinical vision across therapeutic areas, ensuring that programs advance with scientific rigor, regulatory excellence, operational discipline, and cross‑functional alignment. The VP serves as a key advisor to the CMO, a strategic partner to senior leaders across R&D and the broader organization, and a visible representative of the company to external stakeholders including regulatory agencies, investigators, partners, and industry forums.

The VP will shape portfolio strategy, ensure high‑quality data generation, anticipate scientific and regulatory challenges, and build a high‑performing clinical development organization. This role requires exceptional leadership, the ability to navigate complexity, and a deep understanding of the full drug development lifecycle from early translational studies through global registration and commercialization.

The Opportunity to Make a Difference

Strategic Leadership & Vision

• Define and communicate the long‑term vision and strategic direction for Clinical Development, fully aligned with corporate objectives and the CMO's priorities.

• Provide clinical development leadership and direction across all programs, shaping portfolio strategy, development pathways, risk/benefit assessments, and investment decisions.

• Anticipate internal and external factors, including scientific trends, competitive landscape, regulatory expectations, and market dynamics that affect clinical strategy.

• Ensure clinical strategy integrates real‑world evidence, evolving regulatory science, and novel development methodologies where appropriate.

• Serve as a key member of cross‑functional governance bodies (e.g. CSOC and PAC), ensuring clinical perspective informs enterprise decisions.

Cross-functional Leadership & Collaboration

• Partner closely with Development Operations, Biometrics, Regulatory Affairs, Safety, Medical Affairs, CMC, and Commercial to develop integrated development plans and drive program success.

• Oversee development of clinical components of global regulatory filings, including INDs, CTAs, BLAs/MAAs, briefing packages, and responses to regulatory agencies.

• Support business development as required by providing clinical review of potential external opportunities and participate in due diligence assessments

• Facilitate effective decision‑making across the portfolio through clear communication of clinical opportunities, risks, timelines, and dependencies.

Organizational Leadership & Talent Development

• Build, mentor, and lead a high‑performing Clinical Development organization, fostering a culture of scientific rigor, accountability, and collaboration.

• Provide executive‑