Research Senior Technician

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Job Title:

Research Senior Technician

Department:

CCC | Sponsored Research

Research Senior Technician Job Description in Cancer Biology

Description: We are seeking a highly motivated and enthusiastic individual with a bachelor’s degree to join our group as research senior technician.

We are now accepting applications for a Research Senior Technician position in the laboratory of Dr. Triparna Sen at the Department of Internal Medicine, Division of Medical Oncology, Comprehensive Cancer Center at The Ohio State University.

Dr. Sen is a Professor in the Department of Internal Medicine, at The Ohio State University. The Sen lab aims to achieve a systematic and comprehensive understanding of the mechanisms of initiation, progression, and therapeutic resistance in lung cancer. The lab has established the use of multiple high-throughput screening technologies, genomics, proteomics, metabolomics, clinical samples, and animal models to accomplish these goals. The results will lead to the development of novel therapeutic strategies for the clinically relevant molecular subsets of lung cancer.

Position Summary:

The Researcher Senior Technician will be a core technical member of the lab, supporting all aspects of translational research with a focus on:

• CRISPR screening platforms
• Drug dosing studies in both in vitro and in vivo settings
• Clinical sample processing, including the development of patient-derived xenograft (PDX) models

The successful candidate will work closely with postdoctoral fellows and other technical staff and play an integral role in executing experiments, maintaining research infrastructure, and supporting the broader goals of the lab.

Responsibilities:

• Design and execute CRISPR-Cas9-based genetic screens in lung cancer cell models
• Culture and manipulate human lung cancer cell lines and organoids, including transfections and viral transductions
• Perform drug sensitivity assays in vitro and conduct dosing studies in mouse xenograft models
• Establish and maintain PDX and CDX models using immunocompromised mouse strains (NSG, NRG, athymic nude)
• Process human lung tissue specimens for downstream molecular and cellular analyses, including:
  • RNA/protein extraction
  • Flow cytometry and cell sorting
  • Single-cell suspensions for sequencing or culture
• Operate lab equipment including GentleMACS Cell Dissociator, flow cytometers, biosafety cabinets, and centrifuges
• Coordinate mouse studies: monitor health, measure tumor burden, maintain accurate animal records in compliance with IACUC protocols
• Prepare experimental reagents, solutions, and maintain lab stocks
• Organize and update biobank/sample databases and maintain meticulous experimental records in ELN or lab notebooks
• Assist in procurement of lab reagents and equipment, coordinate with administrative staff for ordering and service contracts

Required Qualifications:

• Bacheor’s Degree in Life Sciences or a related field.
• Previous lab experience preferably (but not limited to) in cancer biology.
• Proficiency in cell culture and standard molecular biology techniques.
• Experience handling mice, including tumor implantation and drug administration is a requirement for this position.
• Excellent interpersonal skills, problem-solving flexibility, and adaptabilit