Executive Director, Clinical Development

<p><strong>Description of Role</strong></p> <p>The Executive Director, Clinical Development will play a critical leadership role in advancing Centessa’s clinical programs in sleep-wake disorders and broader CNS indications. Reporting directly to the Senior Vice President, Clinical Development, this leader will assume primary responsibility for the strategic and operational execution of the company’s late-stage Orexin Receptor 2 Agonist Program (Program 750), which targets narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia.</p> <p>Given the broad pipeline within the organization, the Senior Director must bring deep experience spanning preclinical through late-stage clinical development, with the ability to shift fluidly across programs as priorities change.</p> <p>In this highly visible, hands-on role, the Executive Director will collaborate closely with cross-functional partners across Clinical Operations, Regulatory Affairs, Translational Medicine, Biometrics, Safety, and external stakeholders. The individual will provide scientific and medical leadership for clinical study design, execution, data interpretation, and regulatory interactions. This role requires a collaborative and agile mindset, exceptional communication skills, and the ability to influence across a matrixed organization.</p> <p><em>This position is ideal for those seeking:</em></p> <ul> <li>The opportunity to lead a late-stage asset with the potential to transform standard of care for individuals living with sleep-wake disorders</li> <li>A role within a lean, fast-paced, growth-oriented biotech environment requiring deep CNS expertise</li> <li>A collaborative, science-driven, and patient-focused culture</li> <li>A remote working environment with high visibility and strategic impact</li> </ul> <p><strong>Key Responsibilities</strong></p> <ul> <li>Serve as a senior clinical leader for <strong>Program 750</strong>, providing medical and scientific leadership for late-stage development while maintaining readiness to support earlier-stage or emerging programs.</li> <li>Author and oversee clinical study protocols for orexin receptor agonists, ensuring scientific rigor, operational feasibility, and alignment with regulatory expectations.</li> <li>Contribute to and help develop integrated clinical development plans (CDPs) spanning <strong>preclinical translation through late-stage trials</strong>, enabling efficient advancement of multiple candidate molecules.</li> <li>Collaborate closely with Clinical Operations to meet quality, timeline, and budget expectations across all studies within the 750 program and other CNS programs as needed.</li> <li>Provide real-time medical and scientific guidance for ongoing clinical trials, i