Principal Scientist/Antibody Drug Conjugate (ADC) Technology

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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. 

We are looking for an experienced, collaborative, highly motivated scientist and leader with deep expertise in antibody drug conjugates (ADC) technologies. The candidate should have deep understanding and experience antibody drug conjugation technologies. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.

A prove track record of hands-on experience with antibody-drug conjugation chemistry, analytical characterization and developability of ADCs is a must have for this position.

Responsibilities:

• The role will involve leading and carrying out laboratory experiments related to ADC conjugation, associated purification and analytical characterization of the conjugates
• Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence
• Proactively advise and share knowledge and expert opinions with bench scientists, peers and senior management. Mentor staff in troubleshooting strategic and experimental issues
• Record of leading project teams through different stages of pre-clinical discovery
• Ensure highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria
• Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms
• Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
• The candidate will encourage ideas for continuous improvement activities & new technology development and initiative within work group.
• Contribute to patents, publications, and technical reports.

Basic Qualifications:

Bachelor’s Degree with 8+ years of academic or industry experience

Or

Master’s Degree with 6+ years of academic or industry experience

Or

PhD with 4+ years of academic or industry experience

Preferred Qualifications:

A PhD with 4+ years of  industry experience

Extensive hands-on experience with therapeutic antibody and ADC discovery

Deep knowledge of bioconjugation chemistries (lysine, inter-chain cysteine and/or site-specific cysteine and other) is needed.

Experience in development of purification strategies using various chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration (TFF)

Experience in analytical characterization of ADCs including SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC

Experience with biological assays such as measuring cytotoxic activity for ADC characterization.

Hands-on experience with siRNA/ASO conjugations and analytics is a plus.

Demonstrated record of scientific accomplishments and publications.

Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams

For California Sites -  The starting compensation for this job is a range from $121,000 – $167,200, plus incentive cash and stock opp