Principal Scientist Cell Biologist

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.  Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis.  Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro.   LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency.  Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology.  The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate.  Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

The Lead Discovery and Optimization Group within Small Molecule Drug Discovery in San Diego focuses on delivering novel therapeutics for disease intervention by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly driven Principal Scientist to lead junior scientists to identify and characterize small molecule drug candidates for the treatment of human diseases. The successful candidate will work collaboratively in a multi-disciplinary environment to carry out cell-based and molecular assays in support of small molecule discovery for pre-clinical development.

Responsibilities:

• Design and conduct cell based assays for evaluating activity and mechanism of action of small molecule inhibitors/degraders.
• Responsible for technology innovation for high-throughput screening platforms as well as expanding targeted protein degradation assay platforms for E3 ligases.
• Bring strategic insight into program support ensuring robust and innovative solutions and approaches towards the development of high-throughput cell based screens and hit triage assays.  
• Possess strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders.  
• Demonstrate personal leadership within the group, scientific leadership both at the bench and at data analysis and be adept at multi-tasking in a fast-paced environment.
• Establish and maintain working relationship with contract laboratories and relevant collaborators.
• Contribute to the writing of investigator brochures, IND applications, and other regulatory documents when appropriate.

Basic Qualifications: Bachelor's Degree 8+ years of academic / industry experience or Master's Degree 6+ years of academic / industry experience or PhD 4+ years of academic / industry experience

Preferred Qualifications: PhD in Cell Biology, Molecular Biology, or Biochemistry with 4+ years experiences in Biopharmaceutical industry

• Experience in ubiquitin proteasome system (UPS) and E3 ubiquitin ligases is highly essential.
• The successful candidate will be able to clearly demonstrate a consistent track record of impact on drug discovery programs through the judicious use of science and technology. 
• Require superior assay design in cell-based assay formats as well as experience in the application of modern technology.
• Advanced skills in data analysis as well as ability to deploy tools for data integration, data mining and predictive analytics fo