Postdoctoral Scientist - Rosen Lab
Howard Hughes Medical InstituteAbout the role
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About the role:
A Postdoctoral Scientist position is available in the laboratory of Dr. Michael Rosen, in the Department of Biophysics and Howard Hughes Medical Institute at UT Southwestern Medical Center. We seek to recruit individuals who can apply cryoelectron tomography to understand the molecular organization of chromatin and biomolecular condensates in vitro and in cells.
About Department/Lab:
Following on our studies of biochemically reconstituted chromatin condensates (Gibson et al., Cell, 2019; Gibson et al., PNAS, 2023), we have developed methods to determine the higher-order organization of reconstituted and native chromatin in high-pressure frozen, cryoFIB milled samples using cryoET (Zhou, PNAS, 2025; Zhou, bioRxiv, 2025). We now plan to expand this technology to further explore chromatin itself, as well as the structures of various chromatin machines working within condensates. Additionally, we will apply the tools and knowledge to other biomolecular condensates. We will examine both biochemically reconstituted condensates as well as their cellular counterparts, with a goal of relating structural organization to function across a range of length scales (Lyon et al., Nature Reviews Molec Cell Biol, 2021).
Members of the Rosen lab have access to outstanding cryoEM facilities at UTSW, including two Titan Krios microscopes, an Aquilos 2 cryoFIB mill, a Stellaris-5 cryo-confocal light microscope and a Leica EM Ice high pressure freezer; as well as cryoEM instrumentation and expertise at the Janelia campus of the Howard Hughes Medical Institute. Members also benefit from a deep understanding of condensate biophysics, biochemistry and biology within a leading lab in the field.
What we provide:
Relocation Assistance
A competitive compensation package
Opportunity to work in a small, diverse, and encouraging research environment
A flexible schedule
Well-rounded training on techniques and soft skills
One on one mentorship, and support/training for the next stage of your career.
What you’ll do:
Performs research and/or development in collaboration with others for projects.
Makes detailed observations, analyzes data, and interprets results.
Exercises technical discretion in the design, execution, and interpretation of experiments that contribute to project strategies.
Prepares technical reports, summaries, protocols, and quantitative analyses.
Investigates, creates, and develops new methods and technologies for project advancement.
Maintains high level of professional expertise through familiarity with scientific literature, including both conceptual and technical advances.
May participate in scientific conferences and contribute to scientific journals.
May determine methods and procedures on new assignments and may provide guidance to other members of the laboratory.
In addition to the duties specifically identified by this job description, the position will include other duties if and as assigned by the direct supervisor or others with supervisory authority over this position.
Scope :
May supervise the activities of other staff within the laboratory
Shares responsibility for results of a work unit or project team.
Individual able to manage own research project.
What You Bring:
Education:
Ph.D. degree in a scientific discipline
Experience:
Must have experience in cryoelectron microscopy, ideally in cryoelectron tomography and complementary cryoFIB milling.
Skills and Abilities:
Demonstrated working knowledge of scientific principles
Exercises independent judgment in developing methods, techniques, and
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