Director, Oncology Research and Pharmacology

If you are a current Jazz employee please apply via the Internal Career site

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information.

Job Description

Brief Description:

• This individual will be responsible for leading oncology non-clinical pharmacology activities in the Research and Early Development (RNCD) Department.
• Primary responsibilities of Oncology Research and Pharmacology function at Jazz is to establish PK/PD/efficacy relationships and exploring drug mechanism of action, identify predictive disease models and biomarkers, in preclinical settings, to drive the discovery and development of Jazz products and drug candidates.
• This individual will be able to work independently and within ORP and project teams to generate study designs, protocols, review and author reports and co-author primary and secondary pharmacodynamics sections of regulatory documents.
• The scientist is expected to identify, generate and execute study protocols with external CRO’s.
•  Collaborate with and represent the ORP function at internal functional teams including Clinical Development and Operations, Project Management, Bioanalytics and Toxicology to design, develop and implement and monitor execution of strategies and short and long term experiments to advance non-clinical studies in both hematologic cancers and solid tumors.

Essential Functions

• Design and execute experiments to elucidate efficacy, tolerability, mechanism of action biomarkers of efficacy of complex combinations of novel small molecule and biological therapeutics.
• Experience running biochemical or cellular assays, quantitative analysis and biological sample preparation.
• Excellent communication skill with ability to function within ED and in matrixed, cross functional teams.
• Ability to independently design experiments and analyze experimental data and present results in both non-clinical and cross-functional team settings.
• Collaborate with CROs to outsource studies, design via protocols, manage program timing, and costs and with academic labs for Jazz-sponsored research.
• Serve as ED team member and/or lead major pharmacology activities.

Required Knowledge, Skills, and Abilities

• Industry experience investigating therapeutic potential of drug candidates from hit to lead through lead optimization and IND enabling studies
• Diverse background in preclinical oncology with a focus on novel and emerging therapeutic technologies and ability to value opportunity in competitive modalities
• Experience with Immune Oncology (I/O) based therapeutic models and experimental design

• A robust, experience-based understanding of the intersection of cancer signaling pathways and how they can be leveraged for therapeutic advantage
• Experience with identification, development and management of multiple complex pharmacology programs at diverse external contract laboratories.
• Ability to independently design and execute experiments to elucidate efficacy, tolerability, biomarkers of efficacy, mechanism of action of small molecule and biologic therapeutic agents.
• Ability to integrate preclinical and clinical data is essential, as is an ability to innovate and apply novel methods to projects.

• Strong knowledge of analytical programs, including GraphPad Prism.
• Strong leadership skills, high ability to self-start, and desire and competence to network widely within Jazz, the scientific community, and regulatory agencies.
• An ability to integrate preclinical and clinical data is essential, as is an ability to innovate and explore new science
• Excellent analytical skills with experience in biomarker data analysis
• Must be d