Business Performance Director (Chief of Staff)

Career Category

Strategy and Innovation

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Business Performance Director (Chief of Staff)

What you will do

Let’s do this. Let’s change the world! In this vital role you will provide leadership across a broad portfolio of complex, high-visibility initiatives and act as an enterprise connector across Amgen’s site network and global functions.

The Business Performance Director is a senior site leadership role responsible for advancing the strategic, operational, and cultural performance of the Amgen Massachusetts (AMA) site. Reporting to the AMA Site Head, this leader serves as a trusted advisor to the Site Leadership Team (SLT), owning site-wide strategy execution, business performance management, and enterprise-level initiatives that enhance resilience, productivity, and engagement.

This role operates with significant autonomy and influence, integrating strategy, operations, governance, and external engagement across the AMA site.

Specific responsibilities include, but are not limited to:

Site Strategy & Business Performance Leadership

• Lead AMA site strategic planning, including development, execution, tracking, and refinement of 1-year, 3-year, and long-range site strategies aligned to Amgen’s LRP.
• Translate site strategy into an integrated portfolio of prioritized initiatives with clear performance metrics, milestones, and accountability.
• Own site-wide performance management, including dashboards, quarterly business reviews, productivity portfolios, and transformation initiatives.
• Serve as a strategic thought partner to the Site Head and AMA SLT, guiding decision-making on priorities, trade-offs, and risk.

Executive Leadership & Governance

• Act as a senior member of the AMA Site Leadership Team, shaping agendas, facilitating strategic discussions, and independently driving follow-through on leadership decisions.
• Lead high-visibility, cross-site and cross-functional initiatives requiring coordination across PD, Operations, Corporate Affairs, Facilities, HR, Finance, Technology, and EHS.
• Perform Chief-of-Staff–like responsibilities for the Site Head, including preparation of executive-level materials, leadership visits, and enterprise presentations.
• Represent AMA in executive forums, site network discussions, and external engagements as delegated by the Site Head.

Operational Excellence, Risk & Resilience

• Oversee critical site-wide programs including operational excellence, digital transformation, business continuity, risk management, and continuous improvement.
• Develop and maintain the site risk profile, mitigation strategies, and escalation pathways in partnership with the AMA SLT.
• Ensure operational rigor and resilience across the AMA site, proactively identifying risks and driving mitigation strategies.

Facilities, Site Services & Utilization

• Partner with Facilities, Operations, and EHS leaders to ensure AMA maintains high standards for safety, functionality, and employee experience.
• Own site utilization strategy, space planning, and site calendar governance to optimize campus use and support evolving ways of working.
• Collaborate on the deployment and optimization of Amgen’s hybrid work and FlexSpace models at AMA.

Engagement, Culture & External Partnerships

• Partner with Corporate Affairs and site communications to shape consistent, high-impact internal messaging and site engagement strategies.
• Foster strong engagement across Employee Resource Groups (ERGs), site councils, and cross-functional communities.
• Scientific and Business acumen to strengthen Amgen’s presence within the Boston/Cambridge eco