Scientist/Senior Scientist – Biological Analytical Development

Role Description
 

Scientist/Senior Scientist – Biological Analytical Development

Zoetis is a global animal health company dedicated to supporting customers and their businesses. Building on 60 years of experience, we deliver quality medicines, biopharmaceuticals and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.

Zoetis discovers, develops, and manufactures a diverse portfolio of animal health medicines, biopharmaceuticals, and vaccines designed to meet the real-world needs of veterinarians and the livestock farmers and companion animal owners they support.  Zoetis has the first monoclonal antibody therapy for treating atopic dermatitis in dogs.  We are currently seeking to fill new positions to support our growing biopharmaceutical portfolio. 

Zoetis Veterinary Medicine Research and Development, Analytical Sciences, in Kalamazoo, MI, is seeking an analytical scientist at the Scientist/ Senior Scientist level. The successful candidate will possess a strong foundation in protein and/or carbohydrate chemistry. The candidate must be highly motivated to contribute to the characterization of, and novel method development for, biological products. Agility in data analytics is highly preferred.  Self-motivation, excellent problem-solving skills and communication, and an ability to work independently and within a group are essential to this role.

Responsibilities include, but are not limited to, the following:

• Characterization of biological molecules, identify degradation pathways, and define critical quality attributes. Contribute to analytical method development (including streamlining automation for samples preparation), qualification, validation and transfer activities. Primary techniques are HPLC, mass spectrometry, electrophoresis, spectrophotometric, and microplate assays.
• Maintain familiarity with scientific literature and apply new knowledge appropriately to projects.
• Convey complex and nuanced concepts to interdisciplinary teams through oral and written presentations, and reports.
• Work in collaboration with other scientists to advance the development of state-of-the-art techniques to characterize biopharmaceutical products, assays, and tools.  Develop high-throughput and/or automated methodologies for sample preparation.
• Develop creative solutions to moderately complex problems.
• Document and communicate results in laboratory notebooks, technical reports, and oral presentations.
   

Minimum Qualifications:

• PhD in Chemistry, Biochemistry, Computational Biology, or other related discipline, with at least 1-3 years of industry experience, preferably in the biopharmaceutical industry.  BS or MS with extensive industry experience.
• Motivated self-starter with excellent communication (oral and written), interpersonal, and organizational skills.
• Extensive experience in separation technologies including multiple modes for HPLC and capillary electrophoresis (e.g., SEC, RP-HPLC, IEX, icIEF, CE-SDS) for the analysis of complex proteins
• Experience in developing, and validating biopharmaceutical analytical methods, including liquid chromatography (UHPLC and nano LC), electrophoretic separations, glycoprotein analysis, and mass spectrometry.
• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
• Solid understanding of protein structure, post-translational modifications (including glycans) and potential sequence liabilities (e.g oxidation, deamidation, and clipping)
• Prepare comprehensive analytical reports and presentations, conveying findings to both technical and non-technical stakeholders.
• Strong problem-solving skills and a proactive attitude toward process improvement

Preferred Qualifications:

• Proficiency in data analytics tools such as JMP, Tableau, and Minitab, with the ability to manipulate, analyze, and visualize complex data sets.
• Familiarity with peptide mapping by LC-MS/MS (UHPLC and nanoLC), intact mass analysis, MS/MS for protein and carbohydrate structural elucidation.
• Ability to recognize anomalous and inconsistent results and interpret outcomes.
• Familiarity with biopharmaceutical manufacturing processes, including cell culture, purification, and formulation.
• Skills and experience in experimental design, technical problem solving and continuous improvemen