Senior Director Program Management

Join Us in Tackling Autoimmune Disease at Its Root

At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.

When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.

Why Work at Vor?

Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.

Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.

Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.

Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.

 

Vor Biopharma is seeking a highly motivated and experienced Senior Director, Program Management to oversee the strategic and operational management of a late-stage clinical program in autoimmune diseases. This individual will provide leadership across cross-functional teams to ensure successful execution of Phase 3 clinical trials, regulatory interactions, and preparation for potential product launch.

The Director will play a pivotal role in aligning scientific, clinical, regulatory, and commercial strategies to drive the program forward in a fast-paced, small biotech environment.

Key areas of responsibility

Program Leadership

• Lead the overall strategy and execution of a global Phase 3 clinical program in autoimmune diseases.
• Leads effective Program Team meetings and presents program strategy to various audiences
• Accountable for the cross-functional execution of one or more program strategy plans, independent of indication or asset.
• Manages program timeline, cost, quality, and risk mitigation as well as timely escalation where needed
• Acts as a leader in the clinical development organization to help build cross-portfolio capabilities. Recognizes consistent challenges and innovates solutions, shares best practices and coaches more junior staff
• Evaluating new assets, determining time to approval, risks, budget, overall development plan
• Manages the effective operations of Vor Bio cross-functional program teams, focused on the development of one or more disease area programs
• Proactively coordinates risk management and ensures contingency and/or risk mitigation plans are developed

Clinical & Regulatory Oversight

• Partner with Clinical Operations, Medical, Regulatory, and Biostatistics teams to ensure Phase 3 trial execution meets quality, compliance, and regulatory standards.
• Support preparation and submission of regulatory documents (NDA/BLA, briefing books, responses to regulatory queries).
• Oversee interactions with the FDA, EMA, and other global regulatory agencies.

Cross-functional Collaboration

• Lead cross-functional core teams (Clinical, Regulatory, CMC, Commercial, Medical Affairs) to ensure integrated program planning and decision-making.
• Partners with the Program Lead and management to drive development of the Program Strategy Plan, adding value by deriving insights from cross-functional discussions and summarizing those insights in a plan that can be easily communicated and implemented across the enterprise
• Facilitates effective business decisions by ensuring integration of key cross-functional input and robust analysis of scenarios. Ensures all decisions are assessed as to their impacts and communicated to stakeholders in a transparent and timely manner
• Provide clear communication of program progress, risks, and mitigation strategies to executive leadership and the Board of Directors.
• Collaborate with Commercial and Medical Affairs to prepare for launch readiness and market access planning.

External Partnerships

• Manage relationships with CROs, investigators, advisory boards, and key opinion leaders in autoimmune diseases.
• Represent the company at scientific conferences, investor updates, and industry meetings as appropriate.
• Operational & Financial Management
• Oversee program budgets, contracts, and resource planning.
• Identify risks and proactively develop contingency plans to maintain trial integrity a