University of Colorado Anschutz Medical Campus

Department: Biochemistry & Molecular Genetics

Job Title: Research Services Professional (Open Rank: Entry – Principal)

Position #: 00827369 – Requisition #: 38226

Job Summary:

The primary duties of this full-time position will be to perform molecular biology, biochemistry and/or structural biology, and cell culture experiments designed to elucidate the molecular mechanisms of pre-mRNA splicing and its role in disease, as well as the structure and function of the Six1/Eya transcriptional complex for anti-cancer drug design.

Key responsibilities:

• Molecular biology experiments including sub-cloning and mutagenesis 

• Protein and/or RNA expression and purification

• Biochemical and biophysical analyses of protein/protein interaction and/or enzyme function  

• Mammalian cell culture experiments

• Evaluate small molecule compounds in biochemical and cell culture experiments

• If interested, the PRA can learn to prepare EM grids, collect data and determine the cryo-EM structure of protein or protein-RNA complexes 

• Assistance in basic operation of lab, including preparation of solutions and autoclaving material

This description is a summary only and is describing the general level of work being performed, it is not intended to be all-inclusive. The duties of this position may change from time to time and/or based on business need. We reserve the right to add or delete duties and responsibilities at the discretion of the supervisor and/or hiring authority.

Work Location:

Onsite – this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease.

As biochemists and molecular geneticists, we are amid an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Why work for the University?

We have AMAZING benefits and offer exceptional amounts of holiday, vacation and sick leave! The University of Colorado offers an excellent benefits package including: