Senior Scientist III

Why People choose to work at Labcorp: 
At Labcorp, it is our people that make us great – it’s what our clients, our partners and, most importantly, what our employees say. Here, you will have the opportunity to collaborate with extraordinary people with diverse viewpoints. You will discover your own outstanding potential as we build an even stronger organization with industry leaders from early development to the clinic and beyond.  We help our clients develop medicines that improve health and improve lives of their family and friends. 

We have a unique opportunity for a Senior Scientist III with our Immunology & Immunotoxicology department focusing on cell-based and molecular-based assays based at our site in Madison, WI.

Position Summary:

This position will provide scientific expertise to Early Development Safety Assessment and standalone studies over a wide range of Immunology and Immunotoxicology-associated endpoints to support an enhanced solutions-based approach to Clients’ requests. The responsibilities include providing technical input into assay design, troubleshooting problematic assays, and providing technical support and advice for immunoassay-associated study endpoints. They will also lead the development and validation of new cell-based and molecular-based immunoassay methods and dose analysis of cell- and gene therapy-based test articles in compliance with appropriate standard operating procedures (SOPs) and regulatory guidelines.

Education/Experience:

• Required: Master’s degree in biotechnology, immunology, cell biology, toxicology, or relevant discipline area with 5+ years relevant cell-based experience
• Preferred: PhD in biotechnology, immunology, toxicology, cell biology or relevant discipline area
• Extensive experience with cell-based and molecular methods such as flow cytometry, ELISpot, primary and immortalized cell culture, in vitro proliferation and stimulation, DNA/RNA isolation and purification, and qPCR
• Experience in a GLP regulated laboratory environment preferred
• Prior experience in immunoassay method development and validation preferred.

Essential Duties:

• Efficient development and transfer of analytical methods for Immunology and Immunotoxicology, with a focus on cell based and molecular assays such as ELISpot, in vitro cell proliferation assays, PCR (qPCR, q/RT-PCR), primary and immortalized cell culture etc. Methods may also include Flow cytometry, Biomarker assays, Immunofluorescent microscopy, and Immunoassays (Ligand-binding/ELISA).
• This role also works with Study Directors (SD) and other Responsible Analysts (RA) on GLP studies as a main point of contact for analysts and clients, ensuring studies meet I&I assay-associated regulatory requirements and client deadlines.
• Help to obtain new business through client calls, sponsor meetings/inspections and attendance at relevant conferences.
• To conduct, supervise and monitor the development or improvement of analytical methods in compliance with appropriate SOPs, GLPs, and regulatory agency guidelines.
• Independently sets up, performs, and troubleshoots method development, validation, and production use of various assays in conjunction with other scientists.
• Understands and interprets complex protocols and validation plans and actively contributes with recommendations
• Collaborate in research and development for new assays and applications across global I&I
• Demonstrates knowledge of the appropriate regulatory guidelines
• Collaborates with clients to transfer methods into Global Immunology and Immunotoxicology laboratories.
• Maintains and performs routine and non-routine maintenance on general equipment, including problem identification and resolution.
• Alongside the supervisor, effectively plans and utilizes personnel and resources for timely completion of assigned projects
• Conducts and analyzes results from Immunotoxicology assays and proactively anticipates problems that may affect timings, quality etc., and act to resolve them.
• Assists in writing protocols for method development and validation work

Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan.  Casual, PRN & Part Time employees regularly scheduled to work less than 20 hours are eligible to participate in the 401(k) Plan only. For more detailed information, please click here.