Principal Scientist, Cardiovasular, Pulmonary and Renal, Pioneering Medicines

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

About Flagship Pioneering:

Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.  

 Position Summary:

We are seeking an innovative, independent and dynamic lab-based research scientist with broad expertise in molecular and cellular biology to join discovery biology team focused on developing innovative therapeutic drugs in the areas of cardiovascular, renal and pulmonary diseases. This individual will collaborate with in vivo biology, translational science and nonclinical groups to help execute on company strategy.

Key Responsibilities:

• Contribute to the drug discovery process with a goal to  nominate targets with proof of concepts studies
• Act as a leader of a team tasked with screening, characterization, and mechanism of action studies to elucidate signaling pathways for target identification, and validation utilizing  complex cellular models, various modalities, including small molecules, biologics, gene editing , and omics approaches through AI and ML
• Conduct research in areas of cardiovascular, pulmonary and/or renal disease space by acting as a subject matter expertise.
• Lead early drug projects in the cardiovascular, pulmonary and/or renal disease space, propose and champion new targets and novel approaches for disease treatment. 
• Design and execute in vitro and in vivo research plans to evaluate targets modulating pathways in cardiovascular, pulmonary and/or renal diseases
• Develop assays and implement new technologies to enable the delivery of high quality data-driven package and enable project decisions go/no-go portfolio transitions.
• Record and interpret experimental data, and present results to project team members.
• Collaborate with other scientists in a global matrixed dynamic environment fostering innovation and advance project activities. Develop and maintain external relationships/contacts.
•  Deliver impact to projects by identifying technical trends, both internal and external to your subject area.

 

Basic Requirements:

• Ph.D in Biological sciences, or related discipline with  post doctoral experience and a minimum of 3-5 years of research experience  in academic and/or industry experience preferably in cardiovascular, pulmonary and renal therapeutic space.
•  In-depth knowledge of (patho-)physiology of cardiovascular, renal and pulmonary mechanisms, including direct experience complex in vitro cell-based platforms recapitulating human disease phenotype and in vivo models of disease progression
•  Extensive “hands-on” experience and track-record in the use of a wide range of cellular, biochemical and functional assays and technologies to unravel complex cellular signaling pathways.
• Track record of leading discovery projects to elucidate mechanistic target biology and validation in the disease areas.
• A proven scientific impact on innovation through a solid publication track record and strong external scientific network with academic experts.
  * Excellent oral and written English communication skills, with an ability to effectively interact with people in a dynamic matrix environment, both internally and externally
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Additional Qualifications:

• Industrial experience or experience working with academic/industrial collaborators and/or CROs preferred
• Research background in immunology, or metabolism.
• Hands-on experience with genetic-based approaches such as CRISPR and RNA interference is a plus

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Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, g