Scheduled Hours

40

Position Summary

The Senior Scientist in the Cremins Lab will work with a dynamic team to conduct research in the area of sequencing and analysis of complex multimodal genomics data. Collaborate with the team to design, optimize, and standardize experimental and analysis pipelines to accelerate high-quality publications. Develop new code and statistical methods to analyze genomics and spatial transcriptomics datasets to map the neural connectome. They will also be responsible for maintaining and organizing lab records, training junior scientists on technical assays, preparing and reviewing manuscripts, and helping with grant applications.

Successful candidates will possess strong data processing skills in the UNIX/Linux environment and have familiarity with high-performance computing clusters. They will have experience in learning diverse data types generated by various platforms and technologies, including genomics, proteomics, imaging, and spatial transcriptomics data.

This role is ideal for you if you enjoy the excitement of a bleeding-edge scientific laboratory and welcome the challenge of serving as a steady consistent organizational and genomics scientist role in a fast-paced environment. Those who will thrive in the role are dedicated to collaboration and keen on playing an active role in maintaining excellent protocols, a clean, organized, and safe laboratory, and eager to lead themselves and others toward maintaining a warm, positive, and inclusive lab climate. Organized individuals with a can-do attitude, a passion for building unity and community within a larger laboratory, a knack for independent problem-solving and getting things done, and the ability to independently and positively create molecular and cellular data with attention to detail would excel in this role.

Job Description

Primary Duties & Responsibilities:

• Collaborates on designing, conducting and reporting of research projects.
• Supervises and conducts Illumina linkering, library preparation for all genomics experiments, quantification, library pooling, and placing sequencing runs for the lab.
• Generates novel genomics and connectome datasets to understand structure-function relationships of neuronal genomes.
• Assists with grant preparation and reporting.
• Processes and analyzes imaging and sequencing data (image registration, segmentation, feature detection, clustering, anchoring to single cell datasets).
• Prepares and reviews papers on research.
• Develops new algorithms for analysis of RNA FISH, DNA FISH, and neural connectome in situ sequencing technologies.
• Collaborates fluidly with other computational experts to conduct efficient analyses leading to discovery in mammalian neuron genome structure-function data. In parallel, trains to understand the inner workings of loop, TAD, subTAD, and trans interaction code for genome folding in single-cell 3D genome data sets.
• Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Performs other duties as assigned.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological, chemical and radioactive hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Phd Or Terminal Degree Or Combination Of Education And Experience May Substitute For Minimum Education.

Certifications:

No specific certification is required for this position.

Work Experience:

Postdoctoral (3 Years)

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

Preferred Qualifications:

• PhD in cell biology or neuroscience and 5+ years of postdoctoral experience is highly preferred.
• Experience in cell culture, 3D genome architecture, multi-omics, spatial transcriptomics, mouse genetics, and behavioral and circuit neuroscience.
• Experience with Illumina library preparation and handling NextSeq1000/2000 and Novaseq instruments is highly preferred.
• Experience in histology and fluorescence microscopy is highly preferred.
• Experience in Py