Senior Principal Scientist, Translational Development, Pancreatic Cancer Disease Lead

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Translational Medicine at BMS

Translational Medicine is a department within the Research organization that facilitates the transition of drug candidates from early to late-stage clinical development, their approval and life cycle management. Early-stage translational development activities enable rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action and disease segments.

Late-stage translational development activities build upon the early work, additionally exploring mechanisms of resistance, rational drug combinations and product differentiation. The late-stage translational development function is responsible for the translational strategies to support the development of BMS therapies after clinical proof-of-concept studies, including but not limited to regulatory submissions and life-cycle management.

Translational disease strategies in gastrointestinal (GI) malignancies are derived from long term investments in developing data and deep expertise in disease biology, patient segmentation and therapeutic resistance to inform science driven strategies for the development of the GI Oncology pipeline.

This position is an On-Site position located in either Princeton, NJ or Cambridge, MA.

Position Description:

• Develops and executes translational disease strategy in the pancreatic cancer (PC) area with deep disease expertise
• Leads and oversees execution of disease strategy including but not limited to various aspects of patient selection strategies
• Serves as scientific expert in generating novel hypotheses for actionable biology based on novel discoveries integrating disease work with literature and deep expertise in PC biology
• Manages cross-functional disease project teams with key interfaces in IT, bioinformatics, data sciences, biostatistics, external collaborators, contractors, other disease strategy leads and asset leads
• Maintains relationship with physician scientists for identifying new opportunities and for gaining disease insights
• Identifies needs, gaps and translational disease questions and applies knowledge across all assets in BMS portfolio in the PC area
• Leads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients in conjunction with computational biologists, data scientists and statisticians
• Collaborates and guides bioinformatics partners on biological questions to deliver biomarkers and biological understanding from whole transcriptome, whole exome, and/or whole genome data, immune profile and single-cell data to support drug discovery and development in the PC space
• Manages relationships with key internal stakeholders including Regulatory, Clinical,  Commercial, Medical Affairs & Communications and external collaborators to develop translational analysis plans and timelines, communicate analysis results
• Represents the Solid Tumor Translational Development function at various internal meetings and provide domain knowledge and disease expertise to cross-functional teams
• Directs and supports publications in high quality scientific, technical or medical journals

Qualifications:

• PhD degree in a relevant field (e.g. molecular biology, cancer biology, human genetics)
• 4+ years post-PhD experience, with demonstrated scientific leadership in integrating, analyzing and interpreting multimodal translational data in an academic and/or industry setting
• Strong background in human cancer geneti