Senior / Executive Director, Translational Medicine

Relay Therapeutics seeks a dynamic and highly skilled Senior/Executive Director, Translational Medicine leader to build a cutting-edge Translational Medicine team to advance our industry-leading precision medicine pipeline. Bridging research and development, the Senior Director, Translational Medicine will drive all aspects of the translational strategy and will be accountable for delivering key translational milestones from pre-IND to NDA.  The successful candidate will have expertise in precision oncology/rare diseases and be adept at leading cross-functional teams and leveraging novel molecular approaches to advance small molecule therapeutics. 

Your Role:  

• Accountable for generation and continual refinement of the integrated translational medicine strategy for Relay’s precision medicine portfolio from IND to POC to NDA 

• Be a thought partner in cross functional research/clinical teams to devise and advance scientific/medical strategies for key translational milestones across the portfolio including patient selection criteria and companion diagnostics, demonstration of target engagement, principles for dose optimization and proof of mechanism.   

• Lead, manage and oversee translational medicine scientists and day to day operations. 

• With clinical team, define and implement translational objectives and endpoints for precision medicine clinical study protocols to achieve rapid proof of concept and clear path to registration in molecularly defined patient populations. 

• Direct and oversee outsourcing and validation of clinical biomarker assays. 

• Oversee the design of data collection and data mining systems. 

• Responsible for providing Translational Medicine representation on Core Teams, Translational and Clinical Sub Teams, providing Translational Medicine input to overall development planning and implementation.  

• Lead the interpretation of data and their presentation in clinical study reports and publications; accountable for the design and execution of exploratory studies in Translational Medicine. 

• Drive publication/presentation of Translational Medicine data in high impact medical/scientific journals and high-profile medical meetings. 

• Provide key contribution to IND, NDA, PMA submissions via authoring/reviewing relevant sections and generating responses. 

• Build successful internal and external links and collaborations, including with contract research organizations, academia and nonprofit organizations, and the ability to analyze complex issues to develop relevant and realistic plans and recommendations will be key to success.  

 

Your Background:  

• PhD or MD and at least 12+ years of broad bio/pharmaceutical industry experience in drug development, with at least 8+ years of direct experience in translational medicine. 

• Successful track record with PMA submissions and CDx approvals in tissue and/or blood-based patient selection markers  

• Experience scaling and building a translational medicine function 

• Deep knowledge and understanding of oncology and genetic diseases, including companion diagnostics; precision oncology drug development paradigms and technical, business, and regulatory approaches.  

• You are passionate about translational medicine and well connected to external experts and highly credible advisors. You have talent and ability in forging and nurturing key partnerships and collaborations with the external scientific community, in