Senior Principal Scientist-Analytical R&D

Role Summary

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.  

At Pfizer, we are always seeking to deliver breakthroughs that change patients' lives. In this role, you'll be working to help us achieve that goal by advancing biotechnologically derived products to the market through innovation and delivery of cutting-edge analytical testing. You will be part of a team which is focused on developing methods and strategies to support product and process development for biotherapeutics and vaccines, including antibodies, antibody-drug conjugates and therapeutic proteins, at all stages of clinical development. You will  work across analytical functions and projects and will also play a role in developing leaders and providing technical counsel to other organizations and senior leadership. 
 
As a Senior Principal Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as an outstanding scientist in your group. With your advanced knowledge of the discipline, you will regularly contribute in multi-disciplinary teams representing the department and influencing cross-functional teams. Your innovation is seen in way you promote the use of novel experimental approaches, create processes, hypotheses and methodologies. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be entrusted with setting objectives and planning resource requirements for projects. You will undertake mentoring activities to guide team members. 
 
It is your hard work and dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.  

Responsibilities 

• Apply technical and functional knowledge to design and independently execute experiments/projects, contributing to the overall direction of project.  Technical areas anticipated: HPLC, LC-MS, dissolution, and spectroscopy (IR,NIR, Raman).

• Act as a scientific resource within own sub-function/therapeutic area/discipline. 

• Develop appropriate drug product analytical control strategies that are aligned with program and regulatory expectations. 

• Provide technical and scientific leadership and represent analytical development on cross functional and cross-departmental program level teams. 

• Develop assay, qualification and transfer timelines which align with the program timelines. 

• Manage individual lab work on drug product candidates with a focus on developing the analytical methods and strategies to support the clinical and commercial aspects of product and process development and controls. 

• Encourage interaction and effective collaboration with project team members, including presenting data at project team meetings; critical review of data; and active involvement in solving technical challenges that arise during development. 

• Ensure that the staff has received appropriate training and that the training is current.  

• Keep abreast of scientific/ technological developments by participating in scientific meetings/ seminars and through regular scientific review.

• Present experimental results at group meetings, project meetings and department meetings.

• Responsible forthe analytical strategies for development of drug product candidates, which may include method development, release and stability testing, characterization and comparability analyses and analytical support for process and formulation development.

• Serve as an analytical sciences resource for the department and project teams, proactively keeping colleagues updated with current scientific trends and technical aspects from conferences, local meetings and literature.

Required Qualifications  

• Doctoral Degree (PhD) in Analytical Science.

• 7+ years of experience in drug product pharmaceutical development function. 

• Excellent written communication skills, including the ability to maintain an accurate. scientific notebook and draft concise written reports, publications and related documents. 

• Experienced with multiple software platforms and package