Senior Principal Scientist/Associate Director, Translational Development, Lung Cancer Disease Lead

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

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Translational Medicine at BMS

Translational medicine is a department within the Research organization that facilitates the transition of drug candidates from early to late-stage clinical development, their approval and life cycle management. Early-stage translational development activities enable rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action and disease segments.

Late-stage translational development activities build upon the early work, additionally exploring mechanisms of resistance, rational drug combinations and product differentiation. The late-stage Translational Development function is responsible for the development of translational strategies to support the development, and maximize the potential, of BMS’s therapies post-clinical proof-of-concept, including registrations and life-cycle management.

Translational disease strategies in  solid tumor oncology are derived from long term investments in developing data and deep expertise in disease biology, patient segments, immunodeficiencies and of therapeutic resistance to assist science driven strategies for the development of the oncology pipeline.

Summary

Reporting to the Solid Tumor Lung Disease Head in Translational Medicine, the incumbent will be part of the translational group and will help develop translational disease strategies in lung cancer across multiple asset programs for approval or life-cycle management in the BMS pipeline. Key responsibility of this role is to effectively collaborate with a cross functional team of asset scientists with deep disease, drug development and business knowledge to help drive an overall translational strategy, working closely with discovery and early development teams, late clinical development as well as with our team of laboratory scientists.

Position Description:

• Develops and executes translational disease strategy in lung disease area with deep disease expertise

• Leads and oversees execution of disease strategy including but not limited to various aspects of patient selection strategies

• Serves as scientific expert in generating novel hypotheses for targetable biologies based on novel discoveries integrating disease work with literature and deep expertise in lung biology

• Manages cross functional disease project teams with key interfaces in IT, bioinformatics, data sci, stats, external collaborators, contractors, other disease strategy leads and asset leads

• Maintains relationship with translational clinicians for identifying new opportunities and for gaining disease insight

• Identifies needs, gaps and translational disease questions and applies knowledge across all assets in BMS portfolio in lung area

• Leads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients in conjunction with computational biologists, data scientists and statisticians

• Collaborate and guide bioinformatics partners on biological questions to deliver biomarkers and biological understanding from whole transcriptome, whole exome, and/or whole genome data, immune profiling and single cell data in order to support drug discovery and development in solid tumor oncology.

• Manage relationships with key internal stakeholders including regulatory, clinical and commercial and scientific communications and external collaborators to develop translational analysis plans and timelines, communicate analys