Vice President, Clinical Business Operations and Strategy

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The Vice President, Clinical Business Strategy and Operations serves as a critical strategic partner to the SVP of Clinical Operations and the Development Leadership Team, driving alignment, execution, and operational excellence related to the business operations of our global clinical programs. This role integrates visionary leadership, high-level strategic planning, organizational enablement, fiscal strategy and governance oversight with leadership of the company’s global clinical business operations activities—ensuring that partnerships, vendors, and financial commitments align with scientific and corporate priorities. The ideal candidate is a seasoned biotech executive who thrives at the intersection of science, strategy, and business operations, with demonstrated expertise in clinical outsourcing, vendor management, cross-functional execution, strategic planning, clinical finance, project management, business planning & operations, leadership and mentoring, and fostering cross organizational collaboration within high-growth scaling biotechnology organizations.  In this role, you will be responsible for the strategic planning, operational design and structure of, and accountable for the implementation and continuation of, procedures, governance and expansions of processes and procedure to enable Revolution Medicines clinical trials and operations.  Specifically, responsibilities include:

• Create long-term strategic direction for Revolution Medicines’ clinical business operations, ensuring that outsourcing models, vendor partnerships, and financial strategies support the company’s integrated R&D and commercialization goals. Shape the enterprise approach to global clinical vendor strategy and operational scalability.

• Serve as trusted advisor and thought partner to the SVP, Clinical Operations, the EVP, Development and the Chief Development Office as well as Development Leadership Team to translate the evolving strategic vision of clinical operations and policies into operational execution.

• Create functional alignment with Finance, Legal and Development functions and leadership for financial and resource deployment with strategic priorities to support timely clinical study execution through budgeting, forecasting, and strategic vendor utilization as well as contract risk and audit readiness.

• Lead transformation of outsourcing and business partnership models to drive efficiency of our clinical trial execution in alignment with our corporate objectives and growth trajectory, expanding to business operations in other Development functions as appropriate

  • Lead the global vendor outsourcing function, responsible for developing, negotiating, and managing agreements with CRO’s clinical vendors, investigators, clinical sites, and strategic partners within clinical operations and development as a whole.

  • Establish standardized contracting frameworks, performance metrics, and SLAs to enhance consistency, speed, and compliance across programs.

  • Design and operationalize a scalable operating model that can deliver required CTA volumes based on RevMed needs by optimizing processes and reducing complexity.

  • Identify gaps, align building of solutions and drive the evaluation, selection, deployment, and oversight of clinical outsourcing agreements processes and practices.

  • Develop and maintain a vendor governance model that ensures transparency, quality, and fiscal responsibility across global partnerships.

  • Establish metrics and governance to ensure performance, compliance, and fiscal responsibility.

  • Implement metrics and dashboards to monitor contracting cycle times, vendor performance, and clinical business operations efficiency.

• Establish functional effectiveness by cultivating leadership capability across the CORE team, broader Clinical Operations & Development functions and embedding a values-driven culture of collaboration, innovation, accountability, growth and strategic foresight.

• Partner with Development Program Management, Business Operations, and other functional leaders (Quality, Regulatory, Finance, Legal) to develop and implement cross-functional processes t