Senior Scientist, Structural Biology

We are hiring a Senior Scientist to gather structural information for the characterization and optimization of novel gene editing tools as a leader of the Structural Biology team. Reporting to the Senior Director, Structural Biology, this position contributes to the determination of critical structural attributes conferring optimal enzyme performance, including the design and preparation of samples for protein structure experiments, the installation of mutations to increase desirable functions, and the miniaturization of complex multi-component systems while increasing specificity and efficiency. 

You will have the opportunity to make a lasting impact as you partner with the Mammalian Cell Translation and Protein Engineering and Optimization teams to translate novel metagenomics-derived cellular machinery into safe and effective gene editing tools. This role will be based in Emeryville, California.

How you’ll contribute: 

• Lead structural biology investigations to understand protein-protein and protein-nucleic acid interactions of novel and engineered systems
• Contribute purified protein, cofactors, and substrates for structural and mechanistic studies
• Lead the preparation of research planning documents and coordinate activities with academic collaborators and commercial research organizations to execute structural studies. 
• Contribute to the engineering of complex systems by identifying, installing, and testing novel protein variants.
• Collaborate with the mammalian cell translation team to design and test protein fusion constructs for increased cell editing efficiency and specificity.

What you bring:

• Ph.D. degree in Biochemistry, Biophysics, Chemistry, or a related discipline
• At least five years of relevant structural biology experience in postdoc and/or biotech industry 
• Advanced proficiency with the structural determination of novel proteins, especially those with multiple subunits, cofactors, or variants
• Experience coupling primary structural models and experimental kinetic data to deconvolute enzymatic mechanism 
• Experience with designing constructs, expressing recombinant proteins in E. coli and mammalian cells, and purifying recalcitrant proteins from microbial extracts
• Effective oral and written communication, prioritization, and organizational skills
• Personality attributes:  
• Able to quickly learn and adapt to new software tools
• Highly collaborative, solutions-oriented, and thrives in a fast-moving startup environment 

California Pay Transparency Disclosure:

This position is classified as exempt under the Federal Labor Standards Act. This position's anticipated base salary range will be $150000 to $170000.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. 

 

About Metagenomi

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.

 

What makes Metagenomi a unique place to work?

• We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.
• We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more! 
• We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.
  
  

 

At Metagenomi, we know that our people drive our success. We are an equal-opportunity e