Scheduled Hours

40

Position Summary

The main goal of our research is to better understand the link between the immune and the central nervous systems. We are particularly focused on how CD8 T cells are activated in the central nervous system, and how we can translate this knowledge into potential therapeutic strategies for neurodegeneration.

Our latest work uncovered an unexpected role of CD8 T cells in a juvenile and slowly progressive form of the neurodegenerative disease Amyotrophic Lateral Sclerosis 4 (ALS4), which is caused by a mutation in the gene SETX. We found that clonally expanded CD8 T cells of likely autoimmune origin are progressively activated in the central nervous system (CNS) and blood of patients and mice. In ALS4 mice, clonal expansion of CD8 T cells in the CNS correlates with disease progression. Starting from these original results, our lab will further explore the role of CD8 T cells in the pathogenesis of several forms of ALS, in both humans and mice.

Techniques include, but are not limited to, molecular biology and cloning, T cell transduction, flow cytometry, imaging, in vitro and in vivo assays, behavioral tests, and RNA-sequencing.

Collaborates on designing, conducting and reporting of research projects.

Job Description

Primary Duties & Responsibilities:

• Collaborates on designing, conducting and reporting of research projects.
• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Develops hypotheses to be tested and ways of testing it.
• Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Manages research project with other institutions and investigators.
• Performs other duties as assigned such as managing mouse colonies and laboratory operations

Working Conditions:

• Works in a laboratory environment with potential exposure to biological, chemical and radioactive hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Phd Or Terminal Degree Or Combination Of Education And Experience May Substitute For Minimum Education.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

Postdoctoral (3 Years)

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles.

Preferred Qualifications

Education:

No additional education unless stated elsewhere in the job posting.

Certifications/Professional Licenses:

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Analytical Problem Solving, Laboratory Instrumentation, Laboratory Processes, Laboratory Techniques, Oral Communications, Teamwork, Working Independently, Written Communication

Grade

R12

Salary Range

$63,400.00 - $115,000.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

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Accommodation

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