Manager, Information Security & Technology
A-Alpha BioAbout the role
A-Alpha Bio is an early-stage and rapidly growing drug discovery company headquartered in Seattle, WA. We are enabling the next generation of high-impact therapeutics by combining high-throughput synthetic biology to measure protein-protein interactions at scale with state-of-the-art machine learning to predict how proteins bind. We partner with leading pharmaceutical and biotechnology companies to enable the discovery of antibodies, molecular glues, and other protein interaction-related drugs. In parallel, we use our wet-lab and computational platforms to discover and develop an internal pipeline of biologics and molecular glues to improve human health.
This role is not open to remote applicants and would require relocation to Seattle, WA.
Starting Salary Range: $135,000 - $169,000 annually
Exemption Status: Exempt
Location Expectations: Hybrid
Reporting To: VP, Finance & Operations
Role Description
A-Alpha Bio is seeking a Manager, Information Security & Technology to own and lead our information security and technology program – encompassing information security, cloud infrastructure, laboratory technology, and technology governance. Success in this role depends on a combination of strategic planning and technical implementation, the ability to build strong internal and external partnerships, and a sense of ownership and accountability for technology outcomes. This position will require direct ownership, execution, and vendor management, rather than delegation through a dedicated internal team.
Key Responsibilities
Cybersecurity Program
- Own the company’s cybersecurity program and NIST-aligned roadmap.
- Maintain security policies and procedures, control reviews, and corrective actions.
- Manage risk assessments, penetration testing, and vulnerability remediation.
- Develop security metrics, risk reporting, and executive dashboards.
- Coordinate awareness and phishing training; support customer security reviews and questionnaires.
Cloud & Infrastructure
- Lead AWS infrastructure and security improvements from risk assessments and operational reviews.
- Manage cloud identity, access, encryption, logging, and monitoring.
- Support disaster recovery and business continuity, partnering with Data Science on secure, maintainable cloud environments.
Network & Systems
- Own office and laboratory network security and architecture.
- Assess, design, and implement network segmentation between corporate and laboratory environments, including compensating controls for legacy laboratory systems.
- Manage firewalls, DNS, secure connectivity, and network access controls.
- Support lab device and instrument integration, partnering with the MSP on reliable infrastructure.
Microsoft 365 & Identity
- Administer Microsoft 365 and Entra ID, including Conditional Access, Intune, identity governance, and endpoint security.
- Manage application registrations, enterprise applications, user provisioning, and privileged access reviews.
Enterprise Applications
- Own administration and governance of key SaaS and enterprise applications with business owners, including access, licensing, integrations, and vendor escalations.
- Coordinate response to application outages and service issues.
AI & Technology Governance
- Establish AI governance and secure-use standards, including an inventory of approved AI tools and platforms.
- Review technology vendors and SaaS applications for security risks.
Technology Program & Vendor Management
- Own MSP and security vendor relationships, performance, and accountability.
- Lead technology, infrastructure, and security projects end-to-end, coordinating changes organization-wide.
- Develop a multi-year technology roadmap and recommend appropriate investments in security, efficiency, and scalability.
Qualifications & Experience
Required
- Bachelor’s degree in a related field with 7+ years of experience in IT, cybersecurity, cloud administration, or technology operations; or an equivalent combination of education and experience.
- Hands-on experience administering and securing AWS cloud environments, Microsoft 365, and Entra ID.
- Experience implementing and operating a cybersecurity program aligned with the NIST Cybersecurity Framework (or comparable),
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