Process Development, Senior Scientist

Company Description

LGC Axolabs offers a unique services portfolio for the development of nucleic acid therapeutics and nucleic acid-based medicines.

As a world leading service provider in oligonucleotide- & mRNA-based therapeutics we are the single organisation to deliver best solutions for nucleic acid therapeutics’ development, ranging from lead ID, across all clinical stages, to commercial supply.

LGC Axolabs is dedicated to highest scientific standards fostered by world class expertise and capabilities in oligonucleotide (bio)-analytics, clinical trial support, and cGMP manufacture.

Job Description

Axolabs, Petaluma is looking for highly a motivated chemist, biochemist and/or chemical engineer to join in our newly commissioned state-of-art therapeutic oligonucleotide GMP manufacturing facility in Petaluma, CA. This individual will work in a Process Development lab to support therapeutic oligonucleotide manufacturing process development, transfer, and trouble-shooting production challenges.

Responsibility:

• Optimize and scale up/down and transfer solid-phase oligonucleotide synthesis, purification, conjugation, and downstream processing methods in preparation for handover to large scale cGMP manufacturing.
• Provide technical and early-stage manufacturing support in the development of therapeutic cGMP manufacturing process and capability, including developing and drafting of manufacturing protocols.
• Provide technical support in root cause failure analysis for production and quality incidents.
• Keep good records of production activities, experimental procedures, and analytical data.
• Maintain the chemistry laboratory space in compliance with safety regulations.
• Provide technical customer support and routine progress updates to clients in conjunction with project manager assigned to each specific project.
• Draft quality documents for process transfer team and campaign summary reports.

Qualifications

• Master Degree or PhD degree in Chemistry or related disciple.
• 3 years postdoctoral/pharma experience with record of publications/presentations at conferences.
• Strong leadership and communications skills will be essential for this position.
• Solid track record in oligonucleotide therapeutics research and development and hands-on working knowledge in nucleoside, nucleotide, nucleic acid, or oligonucleotide chemistry.
• Process development, process transfer, scale up/down modelling, equipment, and Unicorn software experience.
• Expertise in solid phase oligonucleotide synthesis chemistry, anion-exchange and/or reverse-phase chromatography.
• Working in contract development and manufacturing environment, GMP experience is a plus.
• Solid teamwork skills to interface with engineers, chemists, and analysts to ensure smooth laboratory and plant operations.
• Quantitative methods to drive results and demonstrate resilience and persistence in an experimental approach.
• Interacting with customers and providing technical support.

Additional Information

What we offer (US based-employees):

• Competitive compensation with strong bonus program
• Comprehensive medical, dental, and vision benefits for employees and dependents
• FSA/HSA Pre-tax savings plans for health care, childcare, and elder care
• Deductible Buffer Insurance and Critical Illness Insurance
• 401(k) retirement plan with matching employer contribution
• Company-paid short- and long- term disability, life insurance, and employee assistance program
• Flexible work options
• Pet Insurance for our furry friends
• Enhanced Parental leave of 8 additional weeks
• PTO that begins immediately
• Town Hall monthly meeting onsite/virtual, Cheer program where employees are recognized for outstanding work, Company wide social events, frequent catered lunches and much more!

The typical pay range for this role is:

Minimum: $ 93,750 /Yearly

Maximum: $ 115,000 /Yearly

This range represents the low and high end of the anticipated salary range for the California -based position.  The actual base salary will depend on several factors such as: experience, skills, and location.

All your information will be kept confidential according to EEO guidelines.