Executive Director, Early Clinical Development, NHL Program Lead

Legend Biotech is seeking an Executive Director, Clinical Development, to serve as the clinical lead for the Non-Hodgkin Lymphoma program within the Clinical Development organization. This role will be based in Somerset, New Jersey.

Role Overview

The Executive Director, Clinical Development, will provide strategic, and scientific, and medical leadership for Legend Biotech’s non-Hodgkin Lymphoma clinical development program. This individual will serve as the clinical lead for the program, accountable for developing and shaping the lymphoma strategy and executing an integrated clinical development strategy across early-stage and, as appropriate, later-stage development.

The role includes leading first-in-human, dose-escalation, dose-expansion, and proof-of-concept studies. Collaborating on cross-functional clinical development activities, including supporting the delivery of IND submissions, preparation for and participation in regulatory interactions; integrating translational, biomarker, pharmacology, and safety data, and collaborating on clinical operational inputs. Ultimately the individual will drive the generation of high-quality clinical data to support clinical benefit-risk assessment, differentiation, in support of potential registration. The successful candidate will bring deep hematology/oncology expertise, strong judgment, experience needed to advance innovative cell therapies, and the ability to lead effectively in a fast-paced, highly matrixed and dynamic environment.

Key Responsibilities

• Serve as the clinical lead for the Non-Hodgkin Lymphoma program, providing strategic, scientific, and medical leadership across the development lifecycle.
• Develop and execute the integrated clinical development plan, including indication strategy, patient population selection, endpoint strategy, dose-selection rationale, biomarker strategy, safety monitoring approach, and evidence-generation plan.
• Lead the design, execution, monitoring, interpretation, and reporting of first-in-human, dose-escalation, dose-expansion, proof-of-concept, and other early clinical studies.
• Lead or contribute to late-stage clinical development activities when appropriate, including pivotal study strategy, protocol design, data interpretation, and registration-enabling planning.
• Provide clinical leadership for protocols, clinical study reports, investigator brochures, regulatory briefing documents, IND submissions, health authority meeting packages, publications, abstracts, presentations, and other key clinical deliverables.
• Supervision of the NHL clinical development medical director(s) and clinical science team.
• Partner closely with translational science, biomarker, pharmacology, nonclinical, regulatory, safety/pharmacovigilance, biostatistics, data management, clinical operations, project management, CMC, and commercial colleagues to ensure integrated and executable development plans.
• Provide medical and scientific oversight for study conduct, including medical monitoring, eligibility review, safety review, dose-escalation decision-making, data review, and interpretation of emerging clinical data.
• Ensure early development plans reflect contemporary regulatory expectations for oncology drug development, including robust dose optimization, PK/PD integration, biomarker-informed decision-making, and clear benefit-risk assessment.
• Engage with investigators, academic experts, cooperative groups, study sites, and external advisors to supp