Senior IT Program Management & Transformation Manager

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

Crinetics Pharmaceuticals is seeking a highly motivated and strategic Senior IT Program Management & Transformation Manager to lead the successful delivery of cross-functional technology initiatives while driving organizational change and user adoption. This role is critical in ensuring IT-driven projects not only meet business objectives but are embraced by stakeholders across the organization.

This individual will partner closely with IT leadership, functional business teams, external vendors, and change agents to manage program timelines, risks, budgets, and communications—while also deploying structured change management strategies to prepare, support, and enable end users. The ideal candidate brings a balanced blend of project delivery discipline and human-centered change leadership.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

Program & Project Management

• Lead the planning, execution, and delivery of medium-to-large IT projects and programs across infrastructure, applications, SaaS, and business systems.
• Define and manage project scope, schedules, risks, budgets, and deliverables using project management best practices (e.g., Agile, Waterfall, hybrid).
• Coordinate internal teams, third-party vendors, and cross-functional stakeholders to ensure timely, quality delivery.
• Prepare and present program status updates and risks to IT and business leadership.
• Manage vendor engagements, including scope, service delivery, and SLAs.

Change Management & Adoption

• Apply structured change management methodologies (e.g., Prosci, ADKAR) to support user readiness and adoption of new systems and processes.
• Assess change impacts and develop plans for communication, stakeholder engagement, training, and resistance management.
• Develop and deliver change communications in collaboration with corporate communications and business leads.
• Act as a partner for senior leaders and project sponsors to help them fulfill their change leadership roles.

Collaboration & Leadership

• Partner with IT Business Partners, PMO, HR, Corporate Communications, and business stakeholders to align project and change initiatives with broader organizational goals.
• Drive a culture of continuous improvement, learning, and shared accountability within the IT organization.
• Contribute to the development and maturation of IT project and change management capabilities, tools, and templates.

Education and Experience:

Required:

• Bachelor's degree in Information Technology, Business Administration, Organizational Development, or a related field; Master's degree or MBA is a plus.
• 12+ years of progressive experience in IT project management, program delivery, or change management roles.
• Proven experience leading complex IT projects or programs involving systems implementation, process transformation, or digital enablement.
• Formal training and certification in project management (e.g., PMP, PMI-ACP, Agile Product Delivery) and/or change management (e.g., Prosci, CCMP) strongly preferred.
• Experience in life sciences, biotech, healthcare, or similarly regulated industries a plus.
• Excellent communication, facilitation, and stakeholder engagement skills.
• Ability to navigate ambiguity, work across multiple initiatives, and influence without authority.

Preferred:

• Highly organized and precise, with great attention to detail.
• Skilled communicator with a focus on customer service to resolve issues effectively.

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking an