Senior Scientist

Job Title: Senior Scientist – Analytics & Mass Spec 

Location: Cambridge, MA 

At AstraZeneca, we put patients first and strive to meet unmet patient needs worldwide. Working here means being ambitious, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. 

About the Site 

Our Kendall Square site in Cambridge, MA is part of AstraZeneca’s vibrant R&D community and brings together world-class scientific talent, innovative technologies, and collaborative ways of working to discover and develop life-changing medicines for patients around the world. Located in one of the world’s leading biotechnology hubs, the site is designed to foster cross-functional teamwork, scientific innovation, and operational excellence. 

Summary of the Group 

Biologics Engineering (BE) is a large global organization with teams in Cambridge, MA, Gaithersburg, MD and Cambridge, UK, responsible for the discovery and optimization of next-generation biologics to create biological drug candidates across key therapeutic areas. 

Main Duties & Responsibilities 

We are seeking a highly qualified and motivated Senior Scientist to join the Analytics & Mass Spec Group within the multidisciplinary Protein Analytics & Developability team. The successful candidate will play a key role in advancing our capabilities in high throughput intact protein analysis, peptide mapping for post-translational modification, and analytical and developability assessment. Reporting to the Associate Director of the Analytics & Mass Spec Group, the Senior Scientist will work closely with a multidisciplinary team to support various stages of our pipeline projects and give to the enhancement of our technology platforms through mass spectrometry and analytical techniques. 

• Perform and optimize high-throughput (HT) intact protein analysis, including data acquisition, data processing, and reporting for discovery-stage biologics such as antibodies, multispecifics, and various protein reagents. 

• Develop and apply advanced analytical tools, focusing on mass spectrometry and chromatography-based techniques, to characterize discovery-stage biotherapeutics, facilitating critical decision-making. 

• Design and implement peptide mapping assays for protein characterization to support the developability assessment of pipeline projects. 

• Conduct analytical methods to deeply characterize the biophysical and biochemical properties of discovery-stage biologics.   

• Collaborate with the Protein Analytics and Developability team to refine HT assay workflows, ensuring accuracy and reliability in data collection and interpretation. 

• Analyze and interpret complex datasets, providing insights to drive decision-making in pipeline projects. 

• Stay at the forefront of technological advancements in mass spectrometry and other analytical technologies, integrating innovative solutions to enhance current workflows. 

• Participate in cross-functional project teams, giving technical expertise to inform project strategies and directions.