Director, Clinical Genomics Operations & Variant Science – Invitae – Remote

Labcorp is seeking a US remote-based Director of Clinical Genomics Operations & Variant Science to join its Invitae Genetics division!

Responsibilities:

• Provide strategic, technical, and operational leadership for clinical interpretation and reporting across WGS, WES, targeted NGS panels, and chromosomal microarray (CMA)
• Serve as subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards — ensuring scientific rigor, clinical relevance, and regulatory compliance
• Oversee day-to-day operational performance including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents
• Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting using continuous improvement methodologies
• Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate trends to senior leadership
• Ensure delivery of high-quality clinical reports meeting established turnaround time, accuracy, and quality benchmarks
• Lead root-cause analysis and implementation of corrective and preventive actions for complex production issues
• Develop and execute operational strategies aligned with broader organizational OKRs
• Mentor and coach scientists, genetic counselors, and operational partners — fostering a culture of continuous learning and scientific excellence
• Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development to support launch of new assays, tools, and initiatives
• Act as an individual-contributor Director with expectation of transitioning to formal people management within ~6 months

Minimum Qualifications:

• PhD in Biological Sciences, Molecular Genetics, or Human Genetics with 5 years or more of related work experience; OR Master's degree in Genetic Counseling, Biological Sciences, Molecular Genetics, or Human Genetics with 6 years or more of related work experience; OR Bachelor's degree in Genetics, Biological Sciences, Molecular Genetics, or Human Genetics with 7 years or more of related work experience
• 3 years or more of demonstrated expertise in variant interpretation, curation, and clinical reporting for NGS-based assays, including WGS and WES and/or targeted panels. This includes current or previous hands-on variant interpretation experience
• 3 years or more of experience driving operational efficiency and scaling production workflows supporting clinical interpretation and/or reporting
• 3  years or more experience of demonstrated ability to coach, develop, and elevate operational or production teams, with strong organizational and execution skills
• 3  years or more of experience managing or influencing complex initiatives with measurable outcomes in a high-throughput setting
• 5 years or more of experience in operational leadership, including managing a team, workflow optimization, capacity planning, performance metrics, and cross-functional execution

Preferred Qualifications:

• 5 years or more of Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting
• 3 years or more of experience developing, launching, or scaling clinical genomic assays or interpretation programs
• 2 years or more of experience with rapid or NICU whole genome sequencing (NICU WGS) and high-acuity clinical workflows
• 2 years or more of familiarity with copy number variant (CNV) detection and interpretation across CMA and NGS-based platforms
• Lean Six Sigma (Green Belt or higher) certification or equivalent continuous improvement experience
• 3 years or more of experience scaling high-throughput clinical interpretation/reporting operations

Additional Job Standards:

• Background or interest in clinical domains such as oncology, cardiology, neurology, carrier screening, metabolic disorders, pediatrics, or cytogenomics

• Operational leadership supporting clinical interpretation or reporting workflows, including capacity planning, quality management, and process optimization
• Cross-functional collaboration with laboratory, bioinformatics, product, quality, regulatory, or clinical development teams
• Experience supporting the development, launch, or scaling of clinical genomic assays or interpretation programs
• Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility
• Strong understanding of clinical reporting operations, quality systems, and regulated laboratory environments (e.g., CLIA, CAP)
• Proven ability to operate at a Director level, b