Associate Director, Discovery Biology – Protein Homeostasis TRC

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Location: San Diego, CA – US (On-site) 
Reports to: Executive Director, Protein Homeostasis TRC 

The Protein Homeostasis Thematic Research Center (PH TRC) at Bristol Myers Squibb is a premier oncology research engine focused on delivering transformative therapeutics to patients with hematologic malignancies and solid tumors. The TRC is built on BMS's world-class expertise in targeted protein degradation (TPD) and induced proximity technologies, leveraging these paradigm-shifting modalities to attack previously undruggable oncogenic targets and overcome mechanisms of resistance to existing cancer therapies. Our work spans the full arc of discovery from target identification and biological validation to the advancement of first-in-class degraders and molecular glues into clinical development. 

Position Summary 

The Discovery Biology Department within the PH TRC is seeking an exceptionally talented and driven Associate Director with a strong and proven track record in drug discovery within the TPD and induced proximity space, combined with deep expertise in cancer disease biology, particularly in oncology and/or hematological malignancies. This is a pivotal scientific leadership role for a candidate who brings both a rigorous mechanistic understanding of protein degradation biology and an intimate knowledge of the molecular and cellular underpinnings of cancer. 

The successful candidate will be a recognized expert in their field, capable of translating deep disease biology insights into compelling target hypotheses and advancing novel degrader programs from concept to preclinical proof-of-concept. You will lead a team of discovery biologists, partner closely with medicinal chemistry, structural biology, and translational teams, and serve as a key scientific voice in shaping the TPD pipeline strategy at BMS. 

Position Responsibilities 

In the role as an Associate Director within Protein Homeostasis Discovery Biology, the ideal candidate:  

Leadership & Strategy: 

• Lead highly complex, high-impact TPD and induced proximity drug discovery programs, exercising significant scientific autonomy in defining objectives, prioritizing targets, and driving portfolio decisions. 

• Direct cross-functional project teams in the design, execution, and interpretation of preclinical research programs, with a clear emphasis on oncology and hematologic malignancy indications. 

• Develop and champion department strategy for target identification and validation, mechanism-of-action (MoA) characterization, and disease positioning, with a particular focus on leveraging induced proximity biology to address unmet