Principal Scientist/Senior Principal Scientist, Sterile Product Development

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Drug Product Development (DPD)

Our Drug Product Development team is committed to CMC design, development, and commercialization of innovative drug products to improve patient lives. We leverage the best people, collaboration, and cutting-edge innovation to achieve this commitment. BMS’s internal engine of innovation includes unrivaled industry leading expertise in CMC development of small molecules, protein biotherapeutics, protein degraders, and other therapeutic modalities. We collaborate closely with our colleagues in R&D and Commercial to design our drug products. Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.

Position Summary

This position will be part of Sterile Product Development within the Drug Product Development organization located at New Brunswick, NJ. We are seeking a collaborative, self-motivated, and results oriented scientist/engineer with a passion for problem-solving to extend and enhance patient lives, with a focus on formulation and process development.

The successful candidate excels in a collaborative, cross-functional, matrix team environment to enable the development of new injectable drug products for small molecules, biologics, and emerging modalities, including antibody-drug conjugates, gene therapy (viral vector), and nucleic acids with/without encapsulation technologies.

The successful candidate will be responsible for evaluation of novel drug delivery technologies to develop parenteral formulations for diverse therapeutic modalities. These novel drug delivery technologies include, but are not limited to, liquid crystals, PLGAs, and hydrogels. Experience in nanoparticulate systems is desirable. The successful candidate must demonstrate expertise in developing long acting injectables and extended-release formulations, with demonstrated record of nonclinical and clinical translation of these technologies. The candidate will be responsible for developing, characterizing, and testing of polymer or lipid-based formulations, including (but not limited to) liposomal systems. Experience in nanoparticulate systems is desirable. In addition to portfolio-wide contributions listed above, the successful candidate has training and experience in making and characterization of suspensions/emulsions, extended/controlled release and/or tissue targeting constructs, The scientist/engineer will design and execute studies to develop patient-centric parenteral dosage forms and their manufacturing processes to enable clinical and commercial use.  

Responsibilities

• Drive drug product development as a member/leader of multidisciplinary project teams in a matrix environment, striving towards objectives aligned with Drug Product Development goals.
• Proactively apply scientific or engineering expertise to develop solutions to complex technical, operational, and/or business problems which require ingenuity and creativity.
• Evaluate external drug delivery technologies, leveraging external consultants and internal SMEs, and establish new internal and external collaborations.
• Develop parenteral dosage forms for clinical and commercial use throughout various stages of development.
• Conduct process development, optimization and scale-up studies; bring this knowledge to project teams to enable successful drug product technology transfer to clinical manufacturing and commercial sites.
• Generate data and knowledge for regulatory filings through planning and execution of experimental plans with minimal supervision, within project timelines.
• Integrate and interpret research data and present conclusions as appropriate at various project meetings.
• Issue periodic reports and ensure compliance to safety rules and regulations, experimental best practices, electronic laboratory notebook,