Senior Scientist, Analytical Chemistry

Regeneron Pharmaceutical’s Analytical Chemistry Group is seeking a highly motivated Senior Scientist to join our group. Our group apply understanding of various LC-MS platforms and applications to solve analytical challenges. This Senior Scientist will work on LC-MS technology and method development to support analytical characterization of bioconjugates and other therapeutic protein candidates, as well as other modalities. The ideal candidate will have a robust background in mass spectrometry-based analysis of biomolecules, strong critical thinking skills, a passion for science, and effective interpersonal and communication skills to work productively in cross-functional teams and achieve program goals.

A TYPICAL DAY IN THE ROLE OF A SCIENTIST MIGHT LOOK LIKE:

• Design, complete, and effectively communicate analytical characterization of biotherapeutics, including bioconjugates (antibody-drug conjugates, antibody conjugates, antibody oligonucleotide conjugates, etc.), monoclonal and bispecific antibodies, and other modalities (adeno-associated virus, siRNA, etc.) to support drug discovery and development.

• Lead and deliver characterization activities to elucidate product quality attributes, such as post-translational modifications, sequence variants, charge variants, size variants, host cell proteins, etc.

• Identify opportunities to advance LC-MS analysis of biotherapeutics by developing technical innovations that will contribute to future developmental needs and/or efficiency gains.

• Document experiments, results, and findings in electronic laboratory notebook (ELN) entries.

• Present results in internal meetings and external conferences.

• Prepare and review regulatory submission documents including IND, comparability, and BLA reports, as well as manuscripts for publication in peer-reviewed journals.

• Serve as a team representative and provide analytical knowledge and expertise to cross-functional teams.

THIS JOB MIGHT BE FOR YOU IF:

• You are a critical-thinker and excel at identifying and solving problems.

• You thrive in creative and flexible team environments.

• You are self-motivated and can lead and coordinate multiple projects in a timely manner.

• To be successful in this role, candidates must be thorough, diligent, highly efficient, and capable of collaborating within a team and with external partners. Excellent written and verbal communication skills are essential to this position.

To be considered you must have a BS/MS degree +6 years of experience or a PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field, with 2+ years of experience in mass spectrometry-based analysis of proteins and/or other biological molecules (e.g., oligonucleotides, mRNA, lipid nanoparticles, viral vectors). Extensive experience with advanced mass spectrometers (Orbitrap, Q-TOF, Triple Quadrupole, etc.), liquid chromatography, and data processing software (Protein Metrics, Skyline, Chemdraw, Compound Discoverer, Proteome Discoverer, etc.) is desired. Knowledge and hands-on experience in Bioconjugates (ADCs, ACs, AOCs) is a plus.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location.  In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.  For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together.  For that reason, many of Regeneron’s roles are required to be performed on-site.  Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.
 

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, mil