Principal Scientist I, PK Sciences Oncology

Job Description Summary

#LI-Hybrid

About the role:

This position will be located in Cambridge, MA and will not have the ability to be located remotely.

In the role of Principal Scientist, you will collaborate with a cross-disciplinary team to select and characterize new chemical and biologic entities in research and development and implement clinical pharmacology strategies in early and late clinical development. You will represent the PK/PD/ADME discipline on discovery and development project teams, and suggest and implement strategies and tactics to advance high-quality entities in RLT as part of the overall program(s).

 

Job Description

Key responsibilities:

• provide matrix leadership to collaborate, align and influence across the cross-functional team to identify and mitigate key project issues related to the pharmacokinetic sciences discipline (PK, PK/PD, metabolism and clinical pharmacology).
• Represent the PK/PD/ADME/Clinical Pharmacology discipline as per project need, and serve providing scientific expertise on global cross-functional project teams, leading the strategy, design, execution, and analysis of PKS preclinical and clinical studies.
• Work with subject matter experts in PKS and partner groups
• Support PKS components of preclinical and clinical study protocol designs, preclinical and clinical study reports, and investigator brochures, IND, NDA etc. Prepare for Health Authority calls/meetings/discussion and be responsible as PKS representative in these settings.
• Collaborate with other NIBR and GDD functions, bring innovative ideas and approaches, and a leadership, enterprise mindset that inform and influence the overall drug discovery and development process.
• Responsible for the compilation, seeking of approval and updating of Line Function specific elements of development plans to support the TPP (Target Product Profile).
• Evaluate in-licensing opportunities and carry out Due Diligence activities as required.

The specific accountabilities of the role will be based on the stage of the program (preclinical or clinical)

Essential requirements:

• PhD/PharmD in pharmacology/physiology, biochemistry, chemistry, pharmacokinetics/pharmaceutical sciences, or related sciences.
• Preferably 2 plus years of experience in pharmaceutical industry in a field related to PKS (e.g. Drug Metabolism and Pharmacokinetics).
• Familiarity with standard ADME/PK modelling tools such as Phoenix, GastroPlus, etc. is desirable
• Hands-on project experience with low molecular weight, peptides, and biologics modalities desirable;
• Proven record as team player/leader with superior communication skills.
• Demonstrated success working in a matrix environment.
• Excellent written and oral (English) communication skills is a must

Preferred requirements:
Experience with Radiopharmaceuticals
Experience with preclinical and translational development

Benefits and Rewards:

Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook

Commitment to Diversity and Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $118,400 and $177,600/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.