Postdoctoral Research Fellow - Cancer Biology & Proteomics

Academic

Job Category

Faculty Non Bargaining

Job Title

Postdoctoral Research Fellow - Cancer Biology & Proteomics

Department

Lange Laboratory | Department of Pathology and Laboratory Medicine | Faculty of Medicine (Philipp Lange)

Posting End Date

December 11, 2023

Note: Applications will be accepted until 11:59 PM on the day prior to the Posting End Date above.

Job End Date

Dec 31, 2025

The expected pay range for this position is $5,000/month to $6,667/month.

The Lange Lab is a creative, forward looking and nimble team of scientists that analyzes and decodes the human proteome to find new treatment opportunities for children with cancer. In our latest research published in Nature Communications, we establish a strong rational for starting personalized precision diagnostics immediately at diagnosis. We embrace tough challenges and take pride in pushing fundamental research all the way to improving patient’s care – today. Together with our partners, we informed the treatment of patients and paved the way to bring precision oncology to the next level.

If you are a self-motivated Postdoctoral Fellow with strong ability to lead & work collaboratively and well-rounded, hands-on expertise in cancer biology, protein biochemistry and mass spectrometry we would like to hear from you!

JOB SUMMARY:
For our research projects in the Canadian Pediatric Cancer Consortium (CPCC) we are seeking highly skilled and passionate Postdoctoral Fellows. The successful candidate will develop and lead a research project focusing on spatial and single cells proteomics in high-grade childhood brain tumors, sarcomas or infant leukemias. Alternatively, they will advance plasma and extracellular vesicle proteome and immunopeptidome analysis with the goal to establish liquid biopsy testing for select pediatric malignancies.

This is an exciting opportunity to be part of the Canadian Pediatric Cancer Consortium that brings together Clinicians, Scientists, Patients and Policymakers across Canada to re-think pediatric cancer research and care from the ground up. The successful candidate will have direct access to TimsTOF-ultra and Q-Exactive HF mass spectrometers, laser capture microdissection, unique open-flow microfluidic probe systems, clinical specimen and diverse patient derived model systems. There will also be the opportunity to supervise graduate and undergraduate students, gain leadership experience in collaborative projects and contribute to grant applications. If of interest, we will work with the successful candidate in the latter half of their fellowship to develop a secondary project that provides preliminary data for a first independent position and grant.

The successful candidate will be mentored by Dr. Philipp Lange, PhD (Canada Research Chair in Translational Proteomics of Childhood Cancer). The position is fully funded for 2 years with the possibility of extension. We are looking for a team member to spearhead and shape the project over a period of 3-5 years and provide a very dynamic yet supportive interdisciplinary environment with dedicated mentoring and excellent opportunities for continued career development. The start date is flexible.

WORK PERFORMED:

• Conduct basic/translational research in cancer proteomics
• Design, implement and execute research plans
• Provide leadership and strategic direction in collaborative research projects
• Implement and advance new mass spectrometry approaches
• Perform and document lab experiments, data analysis, interpretations with exceptional care and attention to detail following rigorous scientific principles
• Write manuscripts, and present results at internal and external meetings
• Foster research collaborations and work jointly with academic, clinical, industry, and other partners
• Identify funding opportunities and contribute to grant proposals with mentor as a lead or co-applicant
• Lead and mentor junior trainees in the laboratory
• Capable of working independently and in teams
• Attentive to details
• Excellent social, networking and interpersonal skills
• Comfortable with responsibility and uncertainty

QUALIFICATIONS:

• PhD with expertise in proteomics, mass spectrometry and/or cancer biology
• A proven track record with a minimum of 2-3 first author publications in reputable journals
• Strong statistical foundation and expertise in R or python for data analysis
• Fluent in written and spoken English and demonstrated excellence in scientific writing
• Previous experience in proposal/grant writing is an asset
• Exceptional interpersonal and organizational skills