Sr. Research Associate I, Pivotal Purification Process Development

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Job Description
 

*At a future date this position will relocate to the corporate HQ in Foster City, CA

Gilead Sciences is seeking a Sr Research Associate I with experience in protein purification process development to support operations at our biologics development.

Essential Duties and Job Functions:

• Plan and execute assigned experiments that support Process Development activities and project goals.

• Select appropriate methods and techniques for performing experiments.

• Develop skills in data analysis and interpreting experiment outcomes including the ability to evaluate data quality and recognize anomalous results.

• Recommend alternatives, research new methods and techniques and proactively seek out senior personnel to discuss potential solutions to problems.

• Participate in group meetings and present results, data interpretation and conclusions.

• Demonstrate strong verbal communication and interpersonal skills including the ability to explain processes used to achieve results of assigned tasks.

• Work with team oriented, collaborative and problem-solving mindset.

• Always work with safety in mind.

Knowledge, Experience and Skills:

• Preferred degree in Chemical/Biochemical Engineering, Biochemistry, Chemistry or a related scientific discipline.

• Prior experience in biologics purification, with an emphasis on affinity, IEX, and HIC.

• Prior experience in analytical operations: SEC/HPLC, CE (R/NR), HCP testing is beneficial, but not required.

• Knowledge of cGMPs, technology transfer, and scaling up bioprocesses.

• Must be able to work effectively in cross-functional teams.

• Must demonstrate excellent technical writing skills.

• Working understanding of downstream process development including centrifugation, normal and tangential flow filtration, chromatography operations, and virus clearance. The ability to demonstrate hands on experience in several of these areas is expected.  Experience with multiple modalities (mAbs, bispecifics, fusion and antibody drug conjugates, virus particles) produced in microbial and mammalian expression systems is a plus.

• Ability to work effectively within the purification team to help design and execute experiments supporting process definition, optimization, and characterization with an increasing level of independence.

• Ability to collaborate with Technical Operations during technology transfer from process development to GMP manufacturing, including serving as a process development representative during purification operations, providing technical trouble