Principal/Senior Scientist, Computational Chemistry

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

FL94 Inc., is a privately held, early-stage biotechnology company pioneering Protein Editing. At FL94 we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design of protein editing chemistries. FL94 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL94 from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! 

Principal/Senior scientists in the FL94 computational chemistry team will be responsible for triaging and advancing multiple new program opportunities through to pivotal early PoCs and eventual protein editing small molecule development candidates.  All scientists in FL94 chemistry will team up with scientists in ML and proteomics to further expand the reach of our screening platform. 

The preferred candidate will demonstrate most of the following attributes:

• Demonstrated expertise with docking algorithms and their development/deployment, with an emphasis on covalent strategies
• Highly competent in the use of molecular dynamics to study protein-ligand interactions
• Reactivity or reaction modeling an advantage
• Familiarity with the concepts and application of deep-learning/ML
• Experience with integrating various approaches into a broader framework to accomplish complex tasks
• Demonstrated expertise with writing python code
• Capable of working within a broader team of scientists

The successful candidate will have all the following qualifications necessary to perform in a fast-paced, purposeful, highly integrated, and pioneering environment

• PhD in physical or computational sciences relevant to small molecule drug discovery
• 6+ years of pharmaceutical experience as a functional representative on a multifunctional team at various stages of drug discovery including early hit ID and/or LO
• Able to team up with chemistry and machine learning to enable generative models
• Be a thought leader and functional representative in a multi-functional environment tasked with creating first or best in class small molecule editors
• Clear communicator, authentic leadership qualities, open to take and give feedback up, down and across the organization.

More About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $100 billion in aggregate value. To date, Flagship has deployed over $3.1 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises transformative companies, including Moderna (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Seres Therapeutics (NASDAQ: MCRB), Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Generate Biomedicines, Tessera Tx, and others. 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. 

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.