Director, Project Management – IEP & HEOR

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a key leader within the Medical Excellence function, the Director, Project Management Integrated Evidence Planning (IEP) & Health Economics and Outcomes Research (HEOR) will lead cross-functional planning, execution, and governance of integrated evidence generation activities. This role will ensure seamless coordination across the entire company to deliver high-impact evidence that drives clinical adoption, patient access, and differentiation of our pipeline assets.

This is a highly collaborative and visible position requiring strategic thinking, operational excellence, and expertise in medical evidence planning—including real-world evidence (RWE), HEOR, and data generation initiatives aligned with launch strategies and lifecycle management.

Key responsibilities include:

Strategic Program Leadership

• Lead program management for Integrated Evidence Plans (IEP), ensuring alignment across clinical, medical, and market access functions.

• Oversee project planning for HEOR and RWE initiatives to support product value proposition, access, and payer engagement strategies.

• Serve as program lead for evidence generation planning in preparation for key milestones such as NDA submissions, HTA reviews, and global product launches.

Cross-Functional Coordination

• Facilitate collaboration between Global Medical Affairs, Clinical Development, Biostatistics, Market Access, Regulatory, and Commercial on data generation priorities and execution.

• Drive governance of the Integrated Evidence Working Group (IEWG) and ensure transparent communication of goals, timelines, and deliverables.

• Maintaining regular check-ins with Medical Affairs and key groups to determine IEPs need to be updated.

Operational Execution & Oversight

• Build and manage cross-functional project plans, dashboards, and timelines to monitor progress and mitigate risks across IEP and HEOR initiatives.

• Support internal review, approval, and documentation of evidence generation activities in alignment with compliance and SOPs.

• Maintain calendar of IEP activities.

Process Excellence & Infrastructure

• Champion process improvement and operational efficiency across IEP and HEOR planning cycles.

• Implement tools (e.g., Veeva Medical, Smartsheet) and frameworks to optimize planning, documentation, and tracking of evidence generation deliverables.

• Help to facilitate broad IEP development and implementation.

Stakeholder Engagement & Communication

• Coordinate with external stakeholders including research collaborators, data vendors, and HEOR partners to ensure timely and high-quality execution.

• Drive preparation and delivery of cross-functional updates, dashboards, and communication materials for senior leadership and governance committees.

• Work across Medical Affairs and RWE/HEOR leadership to ensure engagement and alignment of all evidence generation activities.

Team Leadership & Vendor Management

• Provide guidance and oversight to junior project management staff and contractors.

• Oversee vendor performance and budget adherence for outsourced HEOR, RWE, or medical data generation services.

Required Skills, Experience and Education:

• Bachelor’s degree required; advanced degree (MS, MPH, PharmD, PhD, MBA) or PMP certification strongly preferred.

• 15+ years of experience in biotechnology or pharmaceutical industry (with BS), 13+ years (with MS) or 11+ years (with PharmD/PhD), including 8+ years of direct project/program management in Medical Affairs or Evidence Generation.

• Deep knowledge of HEOR, RWE, and medical affairs data generation practices and compliance frameworks.

• Experience supporting integrated evidence plans, HTA submissions, and cross-functional alignment across medical, access, and commercial.

• Proven ability to lead matrix teams and influence across levels and disciplines.